Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice
Microalgae are rich in macronutrients and therefore, they have been proposed as a potential future food source preserving natural resources. Here, we studied safety and bioavailability of algae nutrients in mice. Three microalgae species, Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylu...
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doaj-f1bbf3fb17524456bd5fea28268003092020-11-25T01:41:48ZengMDPI AGNutrients2072-66432018-07-0110896510.3390/nu10080965nu10080965Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 MiceUlrike Neumann0Felix Derwenskus1Andrea Gille2Sandrine Louis3Ulrike Schmid-Staiger4Karlis Briviba5Stephan C. Bischoff6Institute of Clinical Nutrition, University of Hohenheim, Fruwirthstr. 12, 70593 Stuttgart, GermanyInstitute of Interfacial Process Engineering and Plasma Technology, University of Stuttgart, 70569 Stuttgart, GermanyDepartment of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, GermanyInstitute of Clinical Nutrition, University of Hohenheim, Fruwirthstr. 12, 70593 Stuttgart, GermanyFraunhofer Institute for Interfacial Engineering and Biotechnology, 70569 Stuttgart, GermanyDepartment of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, 76131 Karlsruhe, GermanyInstitute of Clinical Nutrition, University of Hohenheim, Fruwirthstr. 12, 70593 Stuttgart, GermanyMicroalgae are rich in macronutrients and therefore, they have been proposed as a potential future food source preserving natural resources. Here, we studied safety and bioavailability of algae nutrients in mice. Three microalgae species, Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum, were studied after ball mill disruption at different doses (5%, 15% and 25% dry weight) for 14 days. In response to all three algae diets, we observed a weight gain similar or superior to that in response to the control diet. No substantial differences in organ weights nor gut length occurred. Protein bioavailability from the algae diets did not differ from the control diet ranging from 58% to 77% apparent biological value. Fat absorption was lower for microalgae compared to soy oil in control diets, albeit still substantial. High liver eicosapentaenoic acid levels were measured following feeding with N. oceanica, the algae richest in omega-3 fatty acids. Neither histological nor serum analyses revealed any heart, kidney or liver toxicity induced by any of the algae diets. Algae-rich diets were thus well accepted, well tolerated and suitable for the maintenance of body weight and normal organ function. No toxicological effects were observed.http://www.mdpi.com/2072-6643/10/8/965microalgaebioavailabilityproteinfatty acidsomega-3 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ulrike Neumann Felix Derwenskus Andrea Gille Sandrine Louis Ulrike Schmid-Staiger Karlis Briviba Stephan C. Bischoff |
spellingShingle |
Ulrike Neumann Felix Derwenskus Andrea Gille Sandrine Louis Ulrike Schmid-Staiger Karlis Briviba Stephan C. Bischoff Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice Nutrients microalgae bioavailability protein fatty acids omega-3 |
author_facet |
Ulrike Neumann Felix Derwenskus Andrea Gille Sandrine Louis Ulrike Schmid-Staiger Karlis Briviba Stephan C. Bischoff |
author_sort |
Ulrike Neumann |
title |
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice |
title_short |
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice |
title_full |
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice |
title_fullStr |
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice |
title_full_unstemmed |
Bioavailability and Safety of Nutrients from the Microalgae Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum in C57BL/6 Mice |
title_sort |
bioavailability and safety of nutrients from the microalgae chlorella vulgaris, nannochloropsis oceanica and phaeodactylum tricornutum in c57bl/6 mice |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-07-01 |
description |
Microalgae are rich in macronutrients and therefore, they have been proposed as a potential future food source preserving natural resources. Here, we studied safety and bioavailability of algae nutrients in mice. Three microalgae species, Chlorella vulgaris, Nannochloropsis oceanica and Phaeodactylum tricornutum, were studied after ball mill disruption at different doses (5%, 15% and 25% dry weight) for 14 days. In response to all three algae diets, we observed a weight gain similar or superior to that in response to the control diet. No substantial differences in organ weights nor gut length occurred. Protein bioavailability from the algae diets did not differ from the control diet ranging from 58% to 77% apparent biological value. Fat absorption was lower for microalgae compared to soy oil in control diets, albeit still substantial. High liver eicosapentaenoic acid levels were measured following feeding with N. oceanica, the algae richest in omega-3 fatty acids. Neither histological nor serum analyses revealed any heart, kidney or liver toxicity induced by any of the algae diets. Algae-rich diets were thus well accepted, well tolerated and suitable for the maintenance of body weight and normal organ function. No toxicological effects were observed. |
topic |
microalgae bioavailability protein fatty acids omega-3 |
url |
http://www.mdpi.com/2072-6643/10/8/965 |
work_keys_str_mv |
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