Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected...
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Centers for Disease Control and Prevention
2010-11-01
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doaj-f1be04a7e1df4d5ba8fd8400c7a964612020-11-25T01:11:14ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592010-11-0116111702170910.3201/eid1611.100628Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, CanadaSonia ToracchioAnnette FoyleVojtech SrollerJon A. ReedJun WuClaudia A. KozinetzJanet S. ButelTo test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence.https://wwwnc.cdc.gov/eid/article/16/11/10-0628_articleVirusesMerkel cell polyomavirusMCPyVhuman polyomaviruseslymphocytescancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sonia Toracchio Annette Foyle Vojtech Sroller Jon A. Reed Jun Wu Claudia A. Kozinetz Janet S. Butel |
spellingShingle |
Sonia Toracchio Annette Foyle Vojtech Sroller Jon A. Reed Jun Wu Claudia A. Kozinetz Janet S. Butel Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada Emerging Infectious Diseases Viruses Merkel cell polyomavirus MCPyV human polyomaviruses lymphocytes cancer |
author_facet |
Sonia Toracchio Annette Foyle Vojtech Sroller Jon A. Reed Jun Wu Claudia A. Kozinetz Janet S. Butel |
author_sort |
Sonia Toracchio |
title |
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada |
title_short |
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada |
title_full |
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada |
title_fullStr |
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada |
title_full_unstemmed |
Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada |
title_sort |
lymphotropism of merkel cell polyomavirus infection, nova scotia, canada |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2010-11-01 |
description |
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence. |
topic |
Viruses Merkel cell polyomavirus MCPyV human polyomaviruses lymphocytes cancer |
url |
https://wwwnc.cdc.gov/eid/article/16/11/10-0628_article |
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