Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy

Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy

Jingjing Kong,1,* Liping Wan,2,* Yanfu Wang,1 Hua Zhang,1 Wei Zhang1 1Department of Geriatrics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Dalian Med...

Full description

Bibliographic Details
Main Authors:	Kong J, Wan L, Wang Y, Zhang H, Zhang W
Format:	Article
Language:	English
Published:	Dove Medical Press 2020-07-01
Series:	Neuropsychiatric Disease and Treatment
Subjects:	alzheimer’s disease glucagonlike peptide 1 autophagy aβ jnk
Online Access:	https://www.dovepress.com/liraglutide-attenuates-abeta42-generation-in-appswesh-sy5y-cells-throu-peer-reviewed-article-NDT

Similar Items

The Role of GI Peptides in Functional Dyspepsia and Gastroparesis: A Systematic Review
by: Karen Van den Houte, et al.
Published: (2020-03-01)

Curcumin reduces hippocampal neuron apoptosis and JNK-3 phosphorylation in rats with Aβ-induced Alzheimer's disease: protecting spatial learning and memory
by: Wang YL, et al.
Published: (2017-06-01)

Computational modeling of the effects of autophagy on amyloid-β peptide levels
by: Kyungreem Han, et al.
Published: (2020-02-01)

Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells
by: Ying Tang, et al.
Published: (2016-06-01)

Soluble Prion Peptide 107–120 Protects Neuroblastoma SH-SY5Y Cells against Oligomers Associated with Alzheimer’s Disease
by: Elham Rezvani Boroujeni, et al.
Published: (2020-10-01)

miR-26 Induces Apoptosis and Inhibits Autophagy in Non-small Cell Lung Cancer Cells by Suppressing TGF-β1-JNK Signaling Pathway
by: Yi He, et al.
Published: (2019-01-01)

Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway
by: Weijun Wang, et al.
Published: (2016-04-01)

Artemisinin attenuated oxidative stress and apoptosis by inhibiting autophagy in MPP+-treated SH-SY5Y cells
by: Junqiang Yan, et al.
Published: (2021-02-01)

Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates
by: Feng Zhang, et al.
Published: (2018-05-01)

Olive Biophenols Reduces Alzheimer’s Pathology in SH-SY5Y Cells and APPswe Mice
by: Syed Haris Omar, et al.
Published: (2018-12-01)

Effect of glutamate on autophagy induced by energy stress in SH-SY5Y neurons
by: Vukotić Tatjana, et al.
Published: (2017-01-01)

Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice
by: Jin Zhang, et al.
Published: (2018-10-01)

Luteolin Isolated from the Medicinal Plant Elsholtzia rugulosa (Labiatae) Prevents Copper-Mediated Toxicity in β-Amyloid Precursor Protein Swedish Mutation Overexpressing SH-SY5Y Cells
by: Guanhua Du, et al.
Published: (2011-03-01)

Targeting autophagy increases the efficacy of proteasome inhibitor treatment in multiple myeloma by induction of apoptosis and activation of JNK
by: Appelmann, I., et al.
Published: (2022)

Ampelopsin inhibits human glioma through inducing apoptosis and autophagy dependent on ROS generation and JNK pathway
by: Zhigang Guo, et al.
Published: (2019-08-01)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
by: Yuan YL, et al.
Published: (2019-08-01)

Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy
by: Dong-Xing Liu, et al.
Published: (2021-03-01)

The Anti-apoptosis Effect of Single Electroacupuncture Treatment via Suppressing Neuronal Autophagy in the Acute Stage of Ischemic Stroke Without Infarct Alleviation
by: Ying Xing, et al.
Published: (2021-02-01)

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway
by: Vanja Vukic, et al.
Published: (2009-04-01)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
by: Jing Chen, et al.
Published: (2021-09-01)

Action of trichostatin A on Alzheimer’s disease-like pathological changes in SH-SY5Y neuroblastoma cells
by: Li-Hua Li, et al.
Published: (2020-01-01)

Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation
by: Seon-Hee Oh, et al.
Published: (2018-07-01)

From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home
by: Margaret M. Harnett, et al.
Published: (2017-02-01)

S1PR2 Inhibition Attenuates Allergic Asthma Possibly by Regulating Autophagy
by: Hanye Liu, et al.
Published: (2021-02-01)

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease
by: Nanbu Wang, et al.
Published: (2020-01-01)

Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug
by: Emanuela Mhillaj, et al.
Published: (2020-09-01)

Resveratrol Modulates Apoptosis and Autophagy Induced by High Glucose and Palmitate in Cardiac Cells
by: Kui Xu, et al.
Published: (2018-04-01)

The Aberrant Expression of the Mesenchymal Variant of FGFR2 in the Epithelial Context Inhibits Autophagy
by: Monica Nanni, et al.
Published: (2019-06-01)

Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice
by: Luisa Müller, et al.
Published: (2021-03-01)

BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation
by: Ganlu Deng, et al.
Published: (2018-07-01)

Neuroprotective Activity of <i>Mentha</i> Species on Hydrogen Peroxide-Induced Apoptosis in SH-SY5Y Cells
by: Doaa M. Hanafy, et al.
Published: (2020-05-01)

Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells
by: Zhu Q, et al.
Published: (2020-04-01)

Role of JIP1-JNK Signaling in Beta-Cell Function and Autophagy
by: Barutcu, Seda
Published: (2018)

Targeting Autophagy Facilitates T Lymphocyte Migration by Inducing the Expression of CXCL10 in Gastric Cancer Cell Lines
by: Qingyuan Meng, et al.
Published: (2020-06-01)

Oligomeric and Fibrillar Species of Aβ42 Diversely Affect Human Neural Stem Cells
by: Adela Bernabeu-Zornoza, et al.
Published: (2021-09-01)

Aβ-40 Y10F Increases βfibrils Formation but Attenuates the Neurotoxicity of Amyloid-β Peptide
by: Zhaofeng Jiang, et al.
Published: (2012-04-01)

β-Asarone Attenuates Aβ-Induced Neuronal Damage in PC12 Cells Overexpressing APPswe by Restoring Autophagic Flux
by: Zhenwan Li, et al.
Published: (2021-07-01)

A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis
by: Di Xue, et al.
Published: (2012-06-01)

Role of amber extract in protecting SHSY5Y cells against amyloid β1-42-induced neurotoxicity
by: Yuening Luo, et al.
Published: (2021-09-01)

Amyloid Β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models
by: Nuno Santos Leal, et al.
Published: (2020-11-01)

Cannot write session to /tmp/vufind_sessions/sess_sk9a1233e82uk4go0palmtbf4j