Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

Abstract Background Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)-...

Full description

Bibliographic Details
Main Authors: Jes Alexander, Gregory M. Findlay, Martin Kircher, Jay Shendure
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Biology
Subjects:
CRISPR/Cas9
Genome editing
Epigenome editing
DNA methylation
HPRT1
Gene silencing
Online Access:http://link.springer.com/article/10.1186/s12915-019-0711-z

Internet

http://link.springer.com/article/10.1186/s12915-019-0711-z

Similar Items