Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation
Abstract This study develops an improved Feldkamp–Davis–Kress (FDK) reconstruction algorithm using non-local total variation (NLTV) denoising and a cubic B-spline interpolation-based backprojector to enhance the image quality of low-dose cone-beam computed tomography (CBCT). The NLTV objective funct...
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doaj-f1cdc4c498234dda98ceaaf57d41d0eb2021-02-14T12:34:47ZengNature Publishing GroupScientific Reports2045-23222021-02-0111111510.1038/s41598-021-83266-1Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolationHo Lee0Jiyoung Park1Yeonho Choi2Kyung Ran Park3Byung Jun Min4Ik Jae Lee5Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Radiation Oncology, Kosin University College of MedicineDepartment of Radiation Oncology, Chungbuk National University HospitalDepartment of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of MedicineAbstract This study develops an improved Feldkamp–Davis–Kress (FDK) reconstruction algorithm using non-local total variation (NLTV) denoising and a cubic B-spline interpolation-based backprojector to enhance the image quality of low-dose cone-beam computed tomography (CBCT). The NLTV objective function is minimized on all log-transformed projections using steepest gradient descent optimization with an adaptive control of the step size to augment the difference between a real structure and noise. The proposed algorithm was evaluated using a phantom data set acquired from a low-dose protocol with lower milliampere-seconds (mAs).The combination of NLTV minimization and cubic B-spline interpolation rendered the enhanced reconstruction images with significantly reduced noise compared to conventional FDK and local total variation with anisotropic penalty. The artifacts were remarkably suppressed in the reconstructed images. Quantitative analysis of reconstruction images using low-dose projections acquired from low mAs showed a contrast-to-noise ratio with spatial resolution comparable to images reconstructed using projections acquired from high mAs. The proposed approach produced the lowest RMSE and the highest correlation. These results indicate that the proposed algorithm enables application of the conventional FDK algorithm for low mAs image reconstruction in low-dose CBCT imaging, thereby eliminating the need for more computationally demanding algorithms. The substantial reductions in radiation exposure associated with the low mAs projection acquisition may facilitate wider practical applications of daily online CBCT imaging.https://doi.org/10.1038/s41598-021-83266-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ho Lee Jiyoung Park Yeonho Choi Kyung Ran Park Byung Jun Min Ik Jae Lee |
spellingShingle |
Ho Lee Jiyoung Park Yeonho Choi Kyung Ran Park Byung Jun Min Ik Jae Lee Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation Scientific Reports |
author_facet |
Ho Lee Jiyoung Park Yeonho Choi Kyung Ran Park Byung Jun Min Ik Jae Lee |
author_sort |
Ho Lee |
title |
Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation |
title_short |
Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation |
title_full |
Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation |
title_fullStr |
Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation |
title_full_unstemmed |
Low-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation |
title_sort |
low-dose cbct reconstruction via joint non-local total variation denoising and cubic b-spline interpolation |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-02-01 |
description |
Abstract This study develops an improved Feldkamp–Davis–Kress (FDK) reconstruction algorithm using non-local total variation (NLTV) denoising and a cubic B-spline interpolation-based backprojector to enhance the image quality of low-dose cone-beam computed tomography (CBCT). The NLTV objective function is minimized on all log-transformed projections using steepest gradient descent optimization with an adaptive control of the step size to augment the difference between a real structure and noise. The proposed algorithm was evaluated using a phantom data set acquired from a low-dose protocol with lower milliampere-seconds (mAs).The combination of NLTV minimization and cubic B-spline interpolation rendered the enhanced reconstruction images with significantly reduced noise compared to conventional FDK and local total variation with anisotropic penalty. The artifacts were remarkably suppressed in the reconstructed images. Quantitative analysis of reconstruction images using low-dose projections acquired from low mAs showed a contrast-to-noise ratio with spatial resolution comparable to images reconstructed using projections acquired from high mAs. The proposed approach produced the lowest RMSE and the highest correlation. These results indicate that the proposed algorithm enables application of the conventional FDK algorithm for low mAs image reconstruction in low-dose CBCT imaging, thereby eliminating the need for more computationally demanding algorithms. The substantial reductions in radiation exposure associated with the low mAs projection acquisition may facilitate wider practical applications of daily online CBCT imaging. |
url |
https://doi.org/10.1038/s41598-021-83266-1 |
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