Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T ce...
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2016-09-01
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Online Access: | https://doi.org/10.1038/ncomms12756 |
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doaj-f1cf2521c0344d9887bd758bdb76df352021-05-11T11:11:43ZengNature Publishing GroupNature Communications2041-17232016-09-017111410.1038/ncomms12756Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1Eri Ishikawa0Hidetaka Kosako1Tomoharu Yasuda2Masaki Ohmuraya3Kimi Araki4Tomohiro Kurosaki5Takashi Saito6Sho Yamasaki7Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu UniversityDivision of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima UniversityLaboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical SciencesInstitute of Resource Development and Analysis, Kumamoto UniversityInstitute of Resource Development and Analysis, Kumamoto UniversityLaboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical SciencesLaboratory for Cell Signaling, RIKEN Center for Integrative Medical SciencesDivision of Molecular Immunology, Medical Institute of Bioregulation, Kyushu UniversityThe three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T cells.https://doi.org/10.1038/ncomms12756 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eri Ishikawa Hidetaka Kosako Tomoharu Yasuda Masaki Ohmuraya Kimi Araki Tomohiro Kurosaki Takashi Saito Sho Yamasaki |
spellingShingle |
Eri Ishikawa Hidetaka Kosako Tomoharu Yasuda Masaki Ohmuraya Kimi Araki Tomohiro Kurosaki Takashi Saito Sho Yamasaki Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 Nature Communications |
author_facet |
Eri Ishikawa Hidetaka Kosako Tomoharu Yasuda Masaki Ohmuraya Kimi Araki Tomohiro Kurosaki Takashi Saito Sho Yamasaki |
author_sort |
Eri Ishikawa |
title |
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 |
title_short |
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 |
title_full |
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 |
title_fullStr |
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 |
title_full_unstemmed |
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 |
title_sort |
protein kinase d regulates positive selection of cd4+ thymocytes through phosphorylation of shp-1 |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-09-01 |
description |
The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T cells. |
url |
https://doi.org/10.1038/ncomms12756 |
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