Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1

The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T ce...

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Main Authors: Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito, Sho Yamasaki
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12756
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spelling doaj-f1cf2521c0344d9887bd758bdb76df352021-05-11T11:11:43ZengNature Publishing GroupNature Communications2041-17232016-09-017111410.1038/ncomms12756Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1Eri Ishikawa0Hidetaka Kosako1Tomoharu Yasuda2Masaki Ohmuraya3Kimi Araki4Tomohiro Kurosaki5Takashi Saito6Sho Yamasaki7Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu UniversityDivision of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima UniversityLaboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical SciencesInstitute of Resource Development and Analysis, Kumamoto UniversityInstitute of Resource Development and Analysis, Kumamoto UniversityLaboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical SciencesLaboratory for Cell Signaling, RIKEN Center for Integrative Medical SciencesDivision of Molecular Immunology, Medical Institute of Bioregulation, Kyushu UniversityThe three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T cells.https://doi.org/10.1038/ncomms12756
collection DOAJ
language English
format Article
sources DOAJ
author Eri Ishikawa
Hidetaka Kosako
Tomoharu Yasuda
Masaki Ohmuraya
Kimi Araki
Tomohiro Kurosaki
Takashi Saito
Sho Yamasaki
spellingShingle Eri Ishikawa
Hidetaka Kosako
Tomoharu Yasuda
Masaki Ohmuraya
Kimi Araki
Tomohiro Kurosaki
Takashi Saito
Sho Yamasaki
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
Nature Communications
author_facet Eri Ishikawa
Hidetaka Kosako
Tomoharu Yasuda
Masaki Ohmuraya
Kimi Araki
Tomohiro Kurosaki
Takashi Saito
Sho Yamasaki
author_sort Eri Ishikawa
title Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_short Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_full Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_fullStr Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_full_unstemmed Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1
title_sort protein kinase d regulates positive selection of cd4+ thymocytes through phosphorylation of shp-1
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+T cells.
url https://doi.org/10.1038/ncomms12756
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