Cytoskeleton and Membrane Organization at Axon Branches
Axon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal growth. This machinery depends on the orchestra...
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doaj-f1d03095b9f64924b60ea0d5625135152021-09-04T00:35:30ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-09-01910.3389/fcell.2021.707486707486Cytoskeleton and Membrane Organization at Axon BranchesSatish Bodakuntla0Hana Nedozralova1Nirakar Basnet2Naoko Mizuno3Naoko Mizuno4Laboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United StatesAxon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal growth. This machinery depends on the orchestration of cellular functions such as cytoskeleton, subcellular transport, energy production, protein- and membrane synthesis that are adapted for branch formation. Compared to the axon shaft, branching sites show a distinct and dynamic arrangement of cytoskeleton components, endoplasmic reticulum and mitochondria. This review discusses the regulation of axon branching in the context of cytoskeleton and membrane remodeling.https://www.frontiersin.org/articles/10.3389/fcell.2021.707486/fullcytoskeletonmitochondriaactinmicrotubulesendoplasmic reticulumaxon branching |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Satish Bodakuntla Hana Nedozralova Nirakar Basnet Naoko Mizuno Naoko Mizuno |
spellingShingle |
Satish Bodakuntla Hana Nedozralova Nirakar Basnet Naoko Mizuno Naoko Mizuno Cytoskeleton and Membrane Organization at Axon Branches Frontiers in Cell and Developmental Biology cytoskeleton mitochondria actin microtubules endoplasmic reticulum axon branching |
author_facet |
Satish Bodakuntla Hana Nedozralova Nirakar Basnet Naoko Mizuno Naoko Mizuno |
author_sort |
Satish Bodakuntla |
title |
Cytoskeleton and Membrane Organization at Axon Branches |
title_short |
Cytoskeleton and Membrane Organization at Axon Branches |
title_full |
Cytoskeleton and Membrane Organization at Axon Branches |
title_fullStr |
Cytoskeleton and Membrane Organization at Axon Branches |
title_full_unstemmed |
Cytoskeleton and Membrane Organization at Axon Branches |
title_sort |
cytoskeleton and membrane organization at axon branches |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-09-01 |
description |
Axon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal growth. This machinery depends on the orchestration of cellular functions such as cytoskeleton, subcellular transport, energy production, protein- and membrane synthesis that are adapted for branch formation. Compared to the axon shaft, branching sites show a distinct and dynamic arrangement of cytoskeleton components, endoplasmic reticulum and mitochondria. This review discusses the regulation of axon branching in the context of cytoskeleton and membrane remodeling. |
topic |
cytoskeleton mitochondria actin microtubules endoplasmic reticulum axon branching |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.707486/full |
work_keys_str_mv |
AT satishbodakuntla cytoskeletonandmembraneorganizationataxonbranches AT hananedozralova cytoskeletonandmembraneorganizationataxonbranches AT nirakarbasnet cytoskeletonandmembraneorganizationataxonbranches AT naokomizuno cytoskeletonandmembraneorganizationataxonbranches AT naokomizuno cytoskeletonandmembraneorganizationataxonbranches |
_version_ |
1717815719378288640 |