Cytoskeleton and Membrane Organization at Axon Branches

Axon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal growth. This machinery depends on the orchestra...

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Main Authors:	Satish Bodakuntla, Hana Nedozralova, Nirakar Basnet, Naoko Mizuno
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	cytoskeleton mitochondria actin microtubules endoplasmic reticulum axon branching
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.707486/full

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spelling	doaj-f1d03095b9f64924b60ea0d5625135152021-09-04T00:35:30ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-09-01910.3389/fcell.2021.707486707486Cytoskeleton and Membrane Organization at Axon BranchesSatish Bodakuntla0Hana Nedozralova1Nirakar Basnet2Naoko Mizuno3Naoko Mizuno4Laboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United StatesNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United StatesAxon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal growth. This machinery depends on the orchestration of cellular functions such as cytoskeleton, subcellular transport, energy production, protein- and membrane synthesis that are adapted for branch formation. Compared to the axon shaft, branching sites show a distinct and dynamic arrangement of cytoskeleton components, endoplasmic reticulum and mitochondria. This review discusses the regulation of axon branching in the context of cytoskeleton and membrane remodeling.https://www.frontiersin.org/articles/10.3389/fcell.2021.707486/fullcytoskeletonmitochondriaactinmicrotubulesendoplasmic reticulumaxon branching
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Satish Bodakuntla Hana Nedozralova Nirakar Basnet Naoko Mizuno Naoko Mizuno
spellingShingle	Satish Bodakuntla Hana Nedozralova Nirakar Basnet Naoko Mizuno Naoko Mizuno Cytoskeleton and Membrane Organization at Axon Branches Frontiers in Cell and Developmental Biology cytoskeleton mitochondria actin microtubules endoplasmic reticulum axon branching
author_facet	Satish Bodakuntla Hana Nedozralova Nirakar Basnet Naoko Mizuno Naoko Mizuno
author_sort	Satish Bodakuntla
title	Cytoskeleton and Membrane Organization at Axon Branches
title_short	Cytoskeleton and Membrane Organization at Axon Branches
title_full	Cytoskeleton and Membrane Organization at Axon Branches
title_fullStr	Cytoskeleton and Membrane Organization at Axon Branches
title_full_unstemmed	Cytoskeleton and Membrane Organization at Axon Branches
title_sort	cytoskeleton and membrane organization at axon branches
publisher	Frontiers Media S.A.
series	Frontiers in Cell and Developmental Biology
issn	2296-634X
publishDate	2021-09-01
description	Axon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal growth. This machinery depends on the orchestration of cellular functions such as cytoskeleton, subcellular transport, energy production, protein- and membrane synthesis that are adapted for branch formation. Compared to the axon shaft, branching sites show a distinct and dynamic arrangement of cytoskeleton components, endoplasmic reticulum and mitochondria. This review discusses the regulation of axon branching in the context of cytoskeleton and membrane remodeling.
topic	cytoskeleton mitochondria actin microtubules endoplasmic reticulum axon branching
url	https://www.frontiersin.org/articles/10.3389/fcell.2021.707486/full
work_keys_str_mv	AT satishbodakuntla cytoskeletonandmembraneorganizationataxonbranches AT hananedozralova cytoskeletonandmembraneorganizationataxonbranches AT nirakarbasnet cytoskeletonandmembraneorganizationataxonbranches AT naokomizuno cytoskeletonandmembraneorganizationataxonbranches AT naokomizuno cytoskeletonandmembraneorganizationataxonbranches
_version_	1717815719378288640

Cytoskeleton and Membrane Organization at Axon Branches

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