A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy Bodies
Neuropathological investigations report that in synucleinopathies with dementia, namely Parkinson’s disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB), the histopathological hallmarks of Alzheimer’s Disease (AD), in particular amyloid plaques, are frequently observed. In this study...
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doaj-f1d244894edd48b49dd97273a66892952020-11-27T08:12:39ZengMDPI AGDiagnostics2075-44182020-11-01101015101510.3390/diagnostics10121015A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy BodiesGiovanni Bellomo0Federico Paolini Paoletti1Elena Chipi2Maya Petricciuolo3Simone Simoni4Nicola Tambasco5Lucilla Parnetti6Laboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, 06132 Perugia (PG), ItalySection of Neurology, Department of Medicine, University of Perugia, 06132 Perugia (PG), ItalySection of Neurology, Department of Medicine, University of Perugia, 06132 Perugia (PG), ItalyLaboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, 06132 Perugia (PG), ItalySection of Neurology, Department of Medicine, University of Perugia, 06132 Perugia (PG), ItalySection of Neurology, Department of Medicine, University of Perugia, 06132 Perugia (PG), ItalyLaboratory of Clinical Neurochemistry, Section of Neurology, Department of Medicine, University of Perugia, 06132 Perugia (PG), ItalyNeuropathological investigations report that in synucleinopathies with dementia, namely Parkinson’s disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB), the histopathological hallmarks of Alzheimer’s Disease (AD), in particular amyloid plaques, are frequently observed. In this study, we investigated the cerebrospinal fluid (CSF) AD biomarkers in different clinical phenotypes of synucleinopathies. CSF Aβ42/Aβ40 ratio, phosphorylated tau and total tau were measured as markers of amyloidosis (A), tauopathy (T) and neurodegeneration (N) respectively, in 98 PD (48 with mild cognitive impairment, PD-MCI; 50 cognitively unimpaired, PD-nMCI), 14 PDD and 15 DLB patients, and 48 neurological controls (CTRL). In our study, CSF AD biomarkers did not significantly differ between CTRL, PD-MCI and PD-nMCI patients. In PD-nMCI and PD-MCI groups, A-/T-/N- profile was the most represented. Prevalence of A+ was similar in PD-nMCI and PD-MCI (10% and 13%, respectively), being higher in PDD (64%) and in DLB (73%). DLB showed the lowest values of Aβ42/Aβ40 ratio. Higher total tau at baseline predicted a worse neuropsychological outcome after one year in PD-MCI. A+/T+, i.e., AD-like CSF profile, was most frequent in the DLB group (40% vs 29% in PDD).https://www.mdpi.com/2075-4418/10/12/1015parkinson’s diseasedementia with lewy bodiesmild cognitive impairmentCSF biomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giovanni Bellomo Federico Paolini Paoletti Elena Chipi Maya Petricciuolo Simone Simoni Nicola Tambasco Lucilla Parnetti |
spellingShingle |
Giovanni Bellomo Federico Paolini Paoletti Elena Chipi Maya Petricciuolo Simone Simoni Nicola Tambasco Lucilla Parnetti A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy Bodies Diagnostics parkinson’s disease dementia with lewy bodies mild cognitive impairment CSF biomarkers |
author_facet |
Giovanni Bellomo Federico Paolini Paoletti Elena Chipi Maya Petricciuolo Simone Simoni Nicola Tambasco Lucilla Parnetti |
author_sort |
Giovanni Bellomo |
title |
A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy Bodies |
title_short |
A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy Bodies |
title_full |
A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy Bodies |
title_fullStr |
A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy Bodies |
title_full_unstemmed |
A/T/(N) Profile in Cerebrospinal Fluid of Parkinson’s Disease with/without Cognitive Impairment and Dementia with Lewy Bodies |
title_sort |
a/t/(n) profile in cerebrospinal fluid of parkinson’s disease with/without cognitive impairment and dementia with lewy bodies |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-11-01 |
description |
Neuropathological investigations report that in synucleinopathies with dementia, namely Parkinson’s disease (PD) with dementia (PDD) and dementia with Lewy bodies (DLB), the histopathological hallmarks of Alzheimer’s Disease (AD), in particular amyloid plaques, are frequently observed. In this study, we investigated the cerebrospinal fluid (CSF) AD biomarkers in different clinical phenotypes of synucleinopathies. CSF Aβ42/Aβ40 ratio, phosphorylated tau and total tau were measured as markers of amyloidosis (A), tauopathy (T) and neurodegeneration (N) respectively, in 98 PD (48 with mild cognitive impairment, PD-MCI; 50 cognitively unimpaired, PD-nMCI), 14 PDD and 15 DLB patients, and 48 neurological controls (CTRL). In our study, CSF AD biomarkers did not significantly differ between CTRL, PD-MCI and PD-nMCI patients. In PD-nMCI and PD-MCI groups, A-/T-/N- profile was the most represented. Prevalence of A+ was similar in PD-nMCI and PD-MCI (10% and 13%, respectively), being higher in PDD (64%) and in DLB (73%). DLB showed the lowest values of Aβ42/Aβ40 ratio. Higher total tau at baseline predicted a worse neuropsychological outcome after one year in PD-MCI. A+/T+, i.e., AD-like CSF profile, was most frequent in the DLB group (40% vs 29% in PDD). |
topic |
parkinson’s disease dementia with lewy bodies mild cognitive impairment CSF biomarkers |
url |
https://www.mdpi.com/2075-4418/10/12/1015 |
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