Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARγ acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally...
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Wolters Kluwer Medknow Publications
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doaj-f1d469bb1d70475f9fda8f6f38b3fa4e2020-11-25T00:32:11ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622015-01-0117694294710.4103/1008-682X.150253Peroxisome proliferator-activated receptor gamma signaling in human sperm physiologyLi-Li LiuHua XianJing-Chen CaoChong ZhangYong-Hui ZhangMiao-Miao ChenYi QianMing JiangPeroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARγ acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPARγ protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARγ signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=6;spage=942;epage=947;aulast=Liufertilization; hypothalamic-pituitary-gonadal axis; insulin resistance; leptin; peroxisome proliferator-activated receptor gamma; sperm physiology; spermatogenesis; spermatozoa |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li-Li Liu Hua Xian Jing-Chen Cao Chong Zhang Yong-Hui Zhang Miao-Miao Chen Yi Qian Ming Jiang |
spellingShingle |
Li-Li Liu Hua Xian Jing-Chen Cao Chong Zhang Yong-Hui Zhang Miao-Miao Chen Yi Qian Ming Jiang Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology Asian Journal of Andrology fertilization; hypothalamic-pituitary-gonadal axis; insulin resistance; leptin; peroxisome proliferator-activated receptor gamma; sperm physiology; spermatogenesis; spermatozoa |
author_facet |
Li-Li Liu Hua Xian Jing-Chen Cao Chong Zhang Yong-Hui Zhang Miao-Miao Chen Yi Qian Ming Jiang |
author_sort |
Li-Li Liu |
title |
Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology |
title_short |
Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology |
title_full |
Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology |
title_fullStr |
Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology |
title_full_unstemmed |
Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology |
title_sort |
peroxisome proliferator-activated receptor gamma signaling in human sperm physiology |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Journal of Andrology |
issn |
1008-682X 1745-7262 |
publishDate |
2015-01-01 |
description |
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARγ acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPARγ protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARγ signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects. |
topic |
fertilization; hypothalamic-pituitary-gonadal axis; insulin resistance; leptin; peroxisome proliferator-activated receptor gamma; sperm physiology; spermatogenesis; spermatozoa |
url |
http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=6;spage=942;epage=947;aulast=Liu |
work_keys_str_mv |
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