Circulating MicroRNAs: Potential Biomarkers for Cancer
Cancer is the leading cause of death in the world. Development of minimally invasive biomarkers for early detection of cancer is urgently needed to reduce high morbidity and mortality associated with malignancy. MicroRNAs (miRNAs) are small regulatory RNAs that modulate the activity of specific mRNA...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2011-03-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/12/3/2055/ |
id |
doaj-f1d5833430ac44c98195bd8d5a817b55 |
---|---|
record_format |
Article |
spelling |
doaj-f1d5833430ac44c98195bd8d5a817b552020-11-25T00:15:13ZengMDPI AGInternational Journal of Molecular Sciences1422-00672011-03-011232055206310.3390/ijms12032055Circulating MicroRNAs: Potential Biomarkers for CancerYi-Tao DingQing-Guo LiXi-Wei DingDe-Cai YuCancer is the leading cause of death in the world. Development of minimally invasive biomarkers for early detection of cancer is urgently needed to reduce high morbidity and mortality associated with malignancy. MicroRNAs (miRNAs) are small regulatory RNAs that modulate the activity of specific mRNA targets and play important roles in a wide range of physiologic and pathologic processes. Recently, miRNAs were found to be dysregulated in a variety of diseases including cancer. Emerging evidence suggests that miRNAs are involved in tumor initiation and progression. Together, the different expression profiles of miRNAs in cancer, and the stability of circulating miRNAs, make them new potentially clinical biomarkers for cancer diagnosis, classification, therapeutic decisions, and prognosis. http://www.mdpi.com/1422-0067/12/3/2055/circulationmicrornaneoplasmbiomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-Tao Ding Qing-Guo Li Xi-Wei Ding De-Cai Yu |
spellingShingle |
Yi-Tao Ding Qing-Guo Li Xi-Wei Ding De-Cai Yu Circulating MicroRNAs: Potential Biomarkers for Cancer International Journal of Molecular Sciences circulation microrna neoplasm biomarkers |
author_facet |
Yi-Tao Ding Qing-Guo Li Xi-Wei Ding De-Cai Yu |
author_sort |
Yi-Tao Ding |
title |
Circulating MicroRNAs: Potential Biomarkers for Cancer |
title_short |
Circulating MicroRNAs: Potential Biomarkers for Cancer |
title_full |
Circulating MicroRNAs: Potential Biomarkers for Cancer |
title_fullStr |
Circulating MicroRNAs: Potential Biomarkers for Cancer |
title_full_unstemmed |
Circulating MicroRNAs: Potential Biomarkers for Cancer |
title_sort |
circulating micrornas: potential biomarkers for cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2011-03-01 |
description |
Cancer is the leading cause of death in the world. Development of minimally invasive biomarkers for early detection of cancer is urgently needed to reduce high morbidity and mortality associated with malignancy. MicroRNAs (miRNAs) are small regulatory RNAs that modulate the activity of specific mRNA targets and play important roles in a wide range of physiologic and pathologic processes. Recently, miRNAs were found to be dysregulated in a variety of diseases including cancer. Emerging evidence suggests that miRNAs are involved in tumor initiation and progression. Together, the different expression profiles of miRNAs in cancer, and the stability of circulating miRNAs, make them new potentially clinical biomarkers for cancer diagnosis, classification, therapeutic decisions, and prognosis. |
topic |
circulation microrna neoplasm biomarkers |
url |
http://www.mdpi.com/1422-0067/12/3/2055/ |
work_keys_str_mv |
AT yitaoding circulatingmicrornaspotentialbiomarkersforcancer AT qingguoli circulatingmicrornaspotentialbiomarkersforcancer AT xiweiding circulatingmicrornaspotentialbiomarkersforcancer AT decaiyu circulatingmicrornaspotentialbiomarkersforcancer |
_version_ |
1725388008822145024 |