Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade

Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in Western countries, and there is still an urgent need for a better understanding of PCa progression to inspire new treatment strategies. Skp2 is a substrate-recruiting component of the E3 ubiquitin ligase complex, wh...

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Bibliographic Details
Main Authors: Alena Mickova, Gvantsa Kharaishvili, Daniela Kurfurstova, Mariam Gachechiladze, Milan Kral, Ondrej Vacek, Barbora Pokryvkova, Martin Mistrik, Karel Soucek, Jan Bouchal
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
Skp2 (S-phase kinase-associated protein 2)
Slug
immunohistochemistry
multiplex
neddylation
Online Access:https://www.mdpi.com/1422-0067/22/6/2844

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