Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies further demonstrate that both geneti...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-05-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/16/5/11055 |
id |
doaj-f1e3ee5a0673434baa7e05b922f9072d |
---|---|
record_format |
Article |
spelling |
doaj-f1e3ee5a0673434baa7e05b922f9072d2020-11-24T21:39:30ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-05-01165110551108610.3390/ijms160511055ijms160511055Molecular Connections between Cancer Cell Metabolism and the Tumor MicroenvironmentCalvin R. Justus0Edward J. Sanderlin1Li V. Yang2Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USADepartment of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USADepartment of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USACancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic metabolism of cancer cells. Reciprocally, altered cancer cell metabolism can modulate the tumor microenvironment which plays important roles in cancer cell somatic evolution, metastasis, and therapeutic response. In this article, we review the progression of current understandings on the molecular interaction between cancer cell metabolism and the tumor microenvironment. In addition, we discuss the implications of these interactions in cancer therapy and chemoprevention.http://www.mdpi.com/1422-0067/16/5/11055tumor microenvironmentcancer cell metabolismhypoxiaacidosiscancer therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Calvin R. Justus Edward J. Sanderlin Li V. Yang |
spellingShingle |
Calvin R. Justus Edward J. Sanderlin Li V. Yang Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment International Journal of Molecular Sciences tumor microenvironment cancer cell metabolism hypoxia acidosis cancer therapy |
author_facet |
Calvin R. Justus Edward J. Sanderlin Li V. Yang |
author_sort |
Calvin R. Justus |
title |
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment |
title_short |
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment |
title_full |
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment |
title_fullStr |
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment |
title_full_unstemmed |
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment |
title_sort |
molecular connections between cancer cell metabolism and the tumor microenvironment |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-05-01 |
description |
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly exists in a variety of tumors. Recent studies further demonstrate that both genetic factors such as oncogenes and tumor suppressors and microenvironmental factors such as spatial hypoxia and acidosis can regulate the glycolytic metabolism of cancer cells. Reciprocally, altered cancer cell metabolism can modulate the tumor microenvironment which plays important roles in cancer cell somatic evolution, metastasis, and therapeutic response. In this article, we review the progression of current understandings on the molecular interaction between cancer cell metabolism and the tumor microenvironment. In addition, we discuss the implications of these interactions in cancer therapy and chemoprevention. |
topic |
tumor microenvironment cancer cell metabolism hypoxia acidosis cancer therapy |
url |
http://www.mdpi.com/1422-0067/16/5/11055 |
work_keys_str_mv |
AT calvinrjustus molecularconnectionsbetweencancercellmetabolismandthetumormicroenvironment AT edwardjsanderlin molecularconnectionsbetweencancercellmetabolismandthetumormicroenvironment AT livyang molecularconnectionsbetweencancercellmetabolismandthetumormicroenvironment |
_version_ |
1725930997873115136 |