The global burden of sepsis: barriers and potential solutions
Abstract Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awarene...
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doaj-f1f882991dfb49fea20a9774b41376122020-11-24T20:50:48ZengBMCCritical Care1364-85352018-09-0122111110.1186/s13054-018-2157-zThe global burden of sepsis: barriers and potential solutionsKristina E. Rudd0Niranjan Kissoon1Direk Limmathurotsakul2Sotharith Bory3Birungi Mutahunga4Christopher W. Seymour5Derek C. Angus6T. Eoin West7International Respiratory and Severe Illness Center, University of WashingtonDivision of Critical Care, Department of Pediatrics, University of British Columbia, British Columbia Children’s HospitalMahidol Oxford Tropical Medicine Research Unit, Mahidol UniversityDivision of Infectious Diseases, Department of Medicine, Calmette HospitalBwindi Community HospitalDepartments of Critical Care and Emergency Medicine, University of Pittsburgh School of MedicineDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine and UPMC Health SystemInternational Respiratory and Severe Illness Center, University of WashingtonAbstract Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy.http://link.springer.com/article/10.1186/s13054-018-2157-zHealth resourcesPovertyPublic healthSepsisLow-income countries |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kristina E. Rudd Niranjan Kissoon Direk Limmathurotsakul Sotharith Bory Birungi Mutahunga Christopher W. Seymour Derek C. Angus T. Eoin West |
spellingShingle |
Kristina E. Rudd Niranjan Kissoon Direk Limmathurotsakul Sotharith Bory Birungi Mutahunga Christopher W. Seymour Derek C. Angus T. Eoin West The global burden of sepsis: barriers and potential solutions Critical Care Health resources Poverty Public health Sepsis Low-income countries |
author_facet |
Kristina E. Rudd Niranjan Kissoon Direk Limmathurotsakul Sotharith Bory Birungi Mutahunga Christopher W. Seymour Derek C. Angus T. Eoin West |
author_sort |
Kristina E. Rudd |
title |
The global burden of sepsis: barriers and potential solutions |
title_short |
The global burden of sepsis: barriers and potential solutions |
title_full |
The global burden of sepsis: barriers and potential solutions |
title_fullStr |
The global burden of sepsis: barriers and potential solutions |
title_full_unstemmed |
The global burden of sepsis: barriers and potential solutions |
title_sort |
global burden of sepsis: barriers and potential solutions |
publisher |
BMC |
series |
Critical Care |
issn |
1364-8535 |
publishDate |
2018-09-01 |
description |
Abstract Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income countries. Barriers to reducing the global burden of sepsis include difficulty quantifying attributable morbidity and mortality, low awareness, poverty and health inequity, and under-resourced and low-resilience public health and acute health care delivery systems. Important differences in the populations at risk, infecting pathogens, and clinical capacity to manage sepsis in high and low-resource settings necessitate context-specific approaches to this significant problem. We review these challenges and propose strategies to overcome them. These strategies include strengthening health systems, accurately identifying and quantifying sepsis cases, conducting inclusive research, establishing data-driven and context-specific management guidelines, promoting creative clinical interventions, and advocacy. |
topic |
Health resources Poverty Public health Sepsis Low-income countries |
url |
http://link.springer.com/article/10.1186/s13054-018-2157-z |
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