Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

Objective: Mutations to the BSCL2 gene disrupt the protein seipin and cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals exhibit a near complete loss of white adipose tissue (WAT) and suffer from metabolic disease. Seipin is critical for adipocyte developm...

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Bibliographic Details
Main Authors: George D. Mcilroy, Karla Suchacki, Anke J. Roelofs, Wulin Yang, Yanyun Fu, Bo Bai, Robert J. Wallace, Cosimo De Bari, William P. Cawthorn, Weiping Han, Mirela Delibegović, Justin J. Rochford
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817310700

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