Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study
Febrile seizure (FS) is the most prevalent childhood seizure; it is significantly related to subsequent epilepsy and has possible links to childhood neurodevelopmental disorders. Separately, premature births are believed to increase the risk of attention deficit hyperactivity disorder (ADHD) and aut...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Life |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-1729/11/8/854 |
id |
doaj-f206bc1b16e6416eb7d0c35105c30420 |
---|---|
record_format |
Article |
spelling |
doaj-f206bc1b16e6416eb7d0c35105c304202021-08-26T13:59:21ZengMDPI AGLife2075-17292021-08-011185485410.3390/life11080854Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective StudyChien-Heng Lin0Wei-De Lin1I-Ching Chou2Inn-Chi Lee3Syuan-Yu Hong4Division of Pediatrics Pulmonology, China Medical University Children’s Hospital, Taichung 404327, TaiwanDepartment of Medical Research, China Medical University Hospital, Taichung 404327, TaiwanDivision of Pediatrics Neurology, China Medical University Children’s Hospital, Taichung 404327, TaiwanDepartment of Pediatrics, Chung Shan Medical University Hospital and Institute of Medicine, School of Medicine, Chung Shan Medical University, Taichung 402306, TaiwanDivision of Pediatrics Neurology, China Medical University Children’s Hospital, Taichung 404327, TaiwanFebrile seizure (FS) is the most prevalent childhood seizure; it is significantly related to subsequent epilepsy and has possible links to childhood neurodevelopmental disorders. Separately, premature births are believed to increase the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Therefore, this study investigated whether preterm birth is a risk factor for subsequent epilepsy, ASD, and ADHD in children with FS. We retrospectively collected data for children aged < 5 years with FS from 1 January 2005, to 31 December 2013. We divided these children into two groups—the premature birth group and the full-term group—and compared their incidence rates of epilepsy, ASD and ADHD. The data of 426 patients with history of febrile convulsion were retrospectively collected. The premature birth group (FS+/preterm+) had 108 patients and the full-term group (FS+/preterm−) had 318 patients. The overall epilepsy risk in the FS+/preterm+ group was higher than in the FS+/preterm− group (odds ratio [OR], 2.52; 95% confidence interval [CI], 1.14–5.58; <i>p</i> = 0.02). The overall risk of ADHD in the FS+/preterm+ group was higher than that in the FS+/preterm− group (OR, 6.41; 95% CI, 3.39–12.09; <i>p</i> = 0.0001). In addition, children with FS+/preterm+ had 16.9 times (95% CI, 4.79–59.7; <i>p</i> = 0.0001) higher odds of having ASD compared with those with FS+/preterm−. Preterm birth may be a risk factor for subsequent epilepsy, ASD and ADHD in children with FS.https://www.mdpi.com/2075-1729/11/8/854epilepsypretermattention deficit hyperactivity disorderautism spectrum disorderneurodevelopmental disorders |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chien-Heng Lin Wei-De Lin I-Ching Chou Inn-Chi Lee Syuan-Yu Hong |
spellingShingle |
Chien-Heng Lin Wei-De Lin I-Ching Chou Inn-Chi Lee Syuan-Yu Hong Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study Life epilepsy preterm attention deficit hyperactivity disorder autism spectrum disorder neurodevelopmental disorders |
author_facet |
Chien-Heng Lin Wei-De Lin I-Ching Chou Inn-Chi Lee Syuan-Yu Hong |
author_sort |
Chien-Heng Lin |
title |
Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study |
title_short |
Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study |
title_full |
Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study |
title_fullStr |
Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study |
title_full_unstemmed |
Is Preterm Birth a Risk Factor for Subsequent Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder in Children with Febrile Seizure?—A Retrospective Study |
title_sort |
is preterm birth a risk factor for subsequent autism spectrum disorder and attention deficit hyperactivity disorder in children with febrile seizure?—a retrospective study |
publisher |
MDPI AG |
series |
Life |
issn |
2075-1729 |
publishDate |
2021-08-01 |
description |
Febrile seizure (FS) is the most prevalent childhood seizure; it is significantly related to subsequent epilepsy and has possible links to childhood neurodevelopmental disorders. Separately, premature births are believed to increase the risk of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Therefore, this study investigated whether preterm birth is a risk factor for subsequent epilepsy, ASD, and ADHD in children with FS. We retrospectively collected data for children aged < 5 years with FS from 1 January 2005, to 31 December 2013. We divided these children into two groups—the premature birth group and the full-term group—and compared their incidence rates of epilepsy, ASD and ADHD. The data of 426 patients with history of febrile convulsion were retrospectively collected. The premature birth group (FS+/preterm+) had 108 patients and the full-term group (FS+/preterm−) had 318 patients. The overall epilepsy risk in the FS+/preterm+ group was higher than in the FS+/preterm− group (odds ratio [OR], 2.52; 95% confidence interval [CI], 1.14–5.58; <i>p</i> = 0.02). The overall risk of ADHD in the FS+/preterm+ group was higher than that in the FS+/preterm− group (OR, 6.41; 95% CI, 3.39–12.09; <i>p</i> = 0.0001). In addition, children with FS+/preterm+ had 16.9 times (95% CI, 4.79–59.7; <i>p</i> = 0.0001) higher odds of having ASD compared with those with FS+/preterm−. Preterm birth may be a risk factor for subsequent epilepsy, ASD and ADHD in children with FS. |
topic |
epilepsy preterm attention deficit hyperactivity disorder autism spectrum disorder neurodevelopmental disorders |
url |
https://www.mdpi.com/2075-1729/11/8/854 |
work_keys_str_mv |
AT chienhenglin ispretermbirthariskfactorforsubsequentautismspectrumdisorderandattentiondeficithyperactivitydisorderinchildrenwithfebrileseizurearetrospectivestudy AT weidelin ispretermbirthariskfactorforsubsequentautismspectrumdisorderandattentiondeficithyperactivitydisorderinchildrenwithfebrileseizurearetrospectivestudy AT ichingchou ispretermbirthariskfactorforsubsequentautismspectrumdisorderandattentiondeficithyperactivitydisorderinchildrenwithfebrileseizurearetrospectivestudy AT innchilee ispretermbirthariskfactorforsubsequentautismspectrumdisorderandattentiondeficithyperactivitydisorderinchildrenwithfebrileseizurearetrospectivestudy AT syuanyuhong ispretermbirthariskfactorforsubsequentautismspectrumdisorderandattentiondeficithyperactivitydisorderinchildrenwithfebrileseizurearetrospectivestudy |
_version_ |
1721192080389177344 |