Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death

Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death

The majority of hearing loss and balance disorders are caused by the permanent loss of mechanosensory hair cells of the inner ear. Identification of genes and compounds that modulate susceptibility to hair cell death is frequently confounded by the difficulties of assaying for such complex phenomena...

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Bibliographic Details
Main Authors: Tamara eStawicki, Robert eEsterberg, Dale eHailey, David W. Raible, Edwin W Rubel
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cisplatin
Zebrafish
Mechanotransduction
Chemical Genetics
Hair cell
Lateral Line
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00046/full

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