Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study
Abstract Background This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or mode...
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2019-12-01
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Series: | International Journal of Behavioral Nutrition and Physical Activity |
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Online Access: | https://doi.org/10.1186/s12966-019-0892-4 |
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English |
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author |
Aina M. Galmes-Panades Veronica Varela-Mato Jadwiga Konieczna Julia Wärnberg Miguel Ángel Martínez-González Jordi Salas-Salvadó Dolores Corella Helmut Schröder Jesús Vioque Ángel M. Alonso-Gómez J. Alfredo Martínez Luís Serra-Majem Ramon Estruch Francisco J. Tinahones José Lapetra Xavier Pintó Josep A. Tur Antonio Garcia-Rios Blanca Riquelme-Gallego José Juan Gaforio Pilar Matía-Martín Lidia Daimiel Rafael Manuel Micó Pérez Josep Vidal Clotilde Vázquez Emilio Ros Ana Garcia-Arellano Andrés Díaz-López Eva M. Asensio Olga Castañer Francisca Fiol Luis Alfredo Mira-Castejón Anai Moreno Rodríguez Juan Carlos Benavente- Marín Itziar Abete Laura Tomaino Rosa Casas F. Javier Barón López José Carlos Fernández-García José Manuel Santos-Lozano Ana Galera Catalina M. Mascaró Cristina Razquin Christopher Papandreou Olga Portoles Karla Alejandra Pérez-Vega Miguel Fiol Laura Compañ-Gabucio Jessica Vaquero-Luna Miguel Ruiz-Canela Nerea Becerra-Tomás Montserrat Fitó Dora Romaguera |
spellingShingle |
Aina M. Galmes-Panades Veronica Varela-Mato Jadwiga Konieczna Julia Wärnberg Miguel Ángel Martínez-González Jordi Salas-Salvadó Dolores Corella Helmut Schröder Jesús Vioque Ángel M. Alonso-Gómez J. Alfredo Martínez Luís Serra-Majem Ramon Estruch Francisco J. Tinahones José Lapetra Xavier Pintó Josep A. Tur Antonio Garcia-Rios Blanca Riquelme-Gallego José Juan Gaforio Pilar Matía-Martín Lidia Daimiel Rafael Manuel Micó Pérez Josep Vidal Clotilde Vázquez Emilio Ros Ana Garcia-Arellano Andrés Díaz-López Eva M. Asensio Olga Castañer Francisca Fiol Luis Alfredo Mira-Castejón Anai Moreno Rodríguez Juan Carlos Benavente- Marín Itziar Abete Laura Tomaino Rosa Casas F. Javier Barón López José Carlos Fernández-García José Manuel Santos-Lozano Ana Galera Catalina M. Mascaró Cristina Razquin Christopher Papandreou Olga Portoles Karla Alejandra Pérez-Vega Miguel Fiol Laura Compañ-Gabucio Jessica Vaquero-Luna Miguel Ruiz-Canela Nerea Becerra-Tomás Montserrat Fitó Dora Romaguera Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study International Journal of Behavioral Nutrition and Physical Activity Inactive time Light physical activity Moderate to vigorous physical activity Time in bed Cardiometabolic risk Isotemporal substitution |
author_facet |
Aina M. Galmes-Panades Veronica Varela-Mato Jadwiga Konieczna Julia Wärnberg Miguel Ángel Martínez-González Jordi Salas-Salvadó Dolores Corella Helmut Schröder Jesús Vioque Ángel M. Alonso-Gómez J. Alfredo Martínez Luís Serra-Majem Ramon Estruch Francisco J. Tinahones José Lapetra Xavier Pintó Josep A. Tur Antonio Garcia-Rios Blanca Riquelme-Gallego José Juan Gaforio Pilar Matía-Martín Lidia Daimiel Rafael Manuel Micó Pérez Josep Vidal Clotilde Vázquez Emilio Ros Ana Garcia-Arellano Andrés Díaz-López Eva M. Asensio Olga Castañer Francisca Fiol Luis Alfredo Mira-Castejón Anai Moreno Rodríguez Juan Carlos Benavente- Marín Itziar Abete Laura Tomaino Rosa Casas F. Javier Barón López José Carlos Fernández-García José Manuel Santos-Lozano Ana Galera Catalina M. Mascaró Cristina Razquin Christopher Papandreou Olga Portoles Karla Alejandra Pérez-Vega Miguel Fiol Laura Compañ-Gabucio Jessica Vaquero-Luna Miguel Ruiz-Canela Nerea Becerra-Tomás Montserrat Fitó Dora Romaguera |
author_sort |
Aina M. Galmes-Panades |
title |
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study |
title_short |
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study |
title_full |
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study |
title_fullStr |
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study |
title_full_unstemmed |
Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus study |
title_sort |
isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the predimed-plus study |
publisher |
BMC |
series |
International Journal of Behavioral Nutrition and Physical Activity |
issn |
1479-5868 |
publishDate |
2019-12-01 |
description |
Abstract Background This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55–75 years, BMI 27–40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health. Trial registration The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered. |
topic |
Inactive time Light physical activity Moderate to vigorous physical activity Time in bed Cardiometabolic risk Isotemporal substitution |
url |
https://doi.org/10.1186/s12966-019-0892-4 |
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doaj-f2228ecba52745a79b57ab54ffeedf9e2020-12-27T12:10:26ZengBMCInternational Journal of Behavioral Nutrition and Physical Activity1479-58682019-12-0116111210.1186/s12966-019-0892-4Isotemporal substitution of inactive time with physical activity and time in bed: cross-sectional associations with cardiometabolic health in the PREDIMED-Plus studyAina M. Galmes-Panades0Veronica Varela-Mato1Jadwiga Konieczna2Julia Wärnberg3Miguel Ángel Martínez-González4Jordi Salas-Salvadó5Dolores Corella6Helmut Schröder7Jesús Vioque8Ángel M. Alonso-Gómez9J. Alfredo Martínez10Luís Serra-Majem11Ramon Estruch12Francisco J. Tinahones13José Lapetra14Xavier Pintó15Josep A. Tur16Antonio Garcia-Rios17Blanca Riquelme-Gallego18José Juan Gaforio19Pilar Matía-Martín20Lidia Daimiel21Rafael Manuel Micó Pérez22Josep Vidal23Clotilde Vázquez24Emilio Ros25Ana Garcia-Arellano26Andrés Díaz-López27Eva M. Asensio28Olga Castañer29Francisca Fiol30Luis Alfredo Mira-Castejón31Anai Moreno Rodríguez32Juan Carlos Benavente- Marín33Itziar Abete34Laura Tomaino35Rosa Casas36F. Javier Barón López37José Carlos Fernández-García38José Manuel Santos-Lozano39Ana Galera40Catalina M. Mascaró41Cristina Razquin42Christopher Papandreou43Olga Portoles44Karla Alejandra Pérez-Vega45Miguel Fiol46Laura Compañ-Gabucio47Jessica Vaquero-Luna48Miguel Ruiz-Canela49Nerea Becerra-Tomás50Montserrat Fitó51Dora Romaguera52Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIISchool of Sport, Exercise and Health Science, Loughborough UniversityCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIIUnit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM)CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos IIICIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos IIIDepartment of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC)Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSICCátedrea Cronicidad Universidad Miguel Hernández. Fundación SEMERGENCIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII)Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIIPublic Health Center Son Serra-La Vileta, Primary Care Management, Balearic Islands Health ServiceRaval Public Health Center, Primary Care ManagementCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIISchool of Health Sciences, University of Málaga-Institute of Biomedical Research in Malaga (IBIMA)Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIISchool of Health Sciences, University of Málaga-Institute of Biomedical Research in Malaga (IBIMA)Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIIMiguel Hernandez University, ISABIAL-FISABIOCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIICentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos IIIAbstract Background This study explored the association between inactive time and measures of adiposity, clinical parameters, obesity, type 2 diabetes and metabolic syndrome components. It further examined the impact of reallocating inactive time to time in bed, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on cardio-metabolic risk factors, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Methods This is a cross-sectional analysis of baseline data from 2189 Caucasian men and women (age 55–75 years, BMI 27–40 Kg/m2) from the PREDIMED-Plus study (http://www.predimedplus.com/). All participants had ≥3 components of the metabolic syndrome. Inactive time, physical activity and time in bed were objectively determined using triaxial accelerometers GENEActiv during 7 days (ActivInsights Ltd., Kimbolton, United Kingdom). Multiple adjusted linear and logistic regression models were used. Isotemporal substitution regression modelling was performed to assess the relationship of replacing the amount of time spent in one activity for another, on each outcome, including measures of adiposity and body composition, biochemical parameters and blood pressure in older adults. Results Inactive time was associated with indicators of obesity and the metabolic syndrome. Reallocating 30 min per day of inactive time to 30 min per day of time in bed was associated with lower BMI, waist circumference and glycated hemoglobin (HbA1c) (all p-values < 0.05). Reallocating 30 min per day of inactive time with 30 min per day of LPA or MVPA was associated with lower BMI, waist circumference, total fat, visceral adipose tissue, HbA1c, glucose, triglycerides, and higher body muscle mass and HDL cholesterol (all p-values < 0.05). Conclusions Inactive time was associated with a poor cardio-metabolic profile. Isotemporal substitution of inactive time with MVPA and LPA or time in bed could have beneficial impact on cardio-metabolic health. Trial registration The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.https://doi.org/10.1186/s12966-019-0892-4Inactive timeLight physical activityModerate to vigorous physical activityTime in bedCardiometabolic riskIsotemporal substitution |