HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells

HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells

Abstract Background Sodium/iodide symporter (NIS)-mediated iodide uptake plays an important physiological role in regulating thyroid gland function, as well as in diagnosing and treating Graves’ disease and thyroid cancer. High-mobility group box 1 (HMGB1), a highly conserved nuclear protein, is a p...

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Bibliographic Details
Main Authors: Wenwen Chai, Fanghua Ye, Li Zeng, Yanling Li, Liangchun Yang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HMGB1
Autophagy
NIS
AMPK
mTOR
Online Access:http://link.springer.com/article/10.1186/s13046-019-1328-3

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