Allicin ameliorates renal ischemia/reperfusion injury via inhibition of oxidative stress and inflammation in rats

• Main Authors: Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
• Format: Article
• Language: English
• Published: Elsevier 2021-10-01
• Series: Biomedicine & Pharmacotherapy
• Subjects: Allicin; Ischemia/reperfusion injury; Oxidative stress; Inflammation; Kidney
• Online Access: http://www.sciencedirect.com/science/article/pii/S075333222100860X

Allicin has been reported to play a biological role in human pathophysiological processes via interaction with numerous signaling pathways and gene expression alteration. The purpose of the present study was to evaluate the protective effects of allicin against renal ischemia/reperfusion injury (RIRI) in rats. In the present study, the RIRI model with 45-min ischemia and 22-h reperfusion in rats was generated and allicin was used as the intervention. Changes in renal tissue pathomorphology, renal function, oxidative stress, inflammatory response and apoptosis were evaluated in the RIRI model in rats. Compared with those in the RIRI group, renal function, renal pathological injury, and anti-inflammatory and antioxidant properties were markedly improved in the RIRI+allicin group. Thus, our research suggested that allicin exerted its protective effect against ischemia/reperfusion-induced renal injury by regulating apoptosis, oxidative stress and inflammatory response in rats.