Two-photon calcium imaging during fictive navigation in virtual environments
A full understanding of nervous system function requires recording from large populations of neurons during naturalistic behaviors. Here we enable paralyzed larval zebrafish to fictively navigate two-dimensional virtual environments while we record optically from many neurons with two-photon imaging...
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Frontiers Media S.A.
2013-06-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00104/full |
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doaj-f233bba6597a4327b966043f9138c1ff2020-11-25T01:08:04ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102013-06-01710.3389/fncir.2013.0010453457Two-photon calcium imaging during fictive navigation in virtual environmentsMisha Benjamin Ahrens0Kuo-Hua eHuang1Sujatha eNarayan2Brett D Mensh3Florian eEngert4Janelia Farm Reserach Campus, Howard Hughes Medical InstituteHarvard UniversityJanelia Farm Reserach Campus, Howard Hughes Medical InstituteJanelia Farm Reserach Campus, Howard Hughes Medical InstituteHarvard UniversityA full understanding of nervous system function requires recording from large populations of neurons during naturalistic behaviors. Here we enable paralyzed larval zebrafish to fictively navigate two-dimensional virtual environments while we record optically from many neurons with two-photon imaging. Electrical recordings from motor nerves in the tail are decoded into intended forward swims and turns, which are used to update a virtual environment displayed underneath the fish. Several behavioral features - such as turning responses to whole-field motion and dark avoidance - are well-replicated in this virtual setting. We readily observed neuronal populations in the hindbrain with laterally selective responses that correlated with right or left optomotor behavior. We also observed neurons in the habenula, pallium, and midbrain with response properties specific to environmental features. Beyond single-cell correlations, the classification of network activity in such virtual settings promises to reveal principles of brainwide neural dynamics during behavior.http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00104/fullBehaviorZebrafishvirtual realitymotor controltwo-photon calcium imagingsensorimotor transformations |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Misha Benjamin Ahrens Kuo-Hua eHuang Sujatha eNarayan Brett D Mensh Florian eEngert |
spellingShingle |
Misha Benjamin Ahrens Kuo-Hua eHuang Sujatha eNarayan Brett D Mensh Florian eEngert Two-photon calcium imaging during fictive navigation in virtual environments Frontiers in Neural Circuits Behavior Zebrafish virtual reality motor control two-photon calcium imaging sensorimotor transformations |
author_facet |
Misha Benjamin Ahrens Kuo-Hua eHuang Sujatha eNarayan Brett D Mensh Florian eEngert |
author_sort |
Misha Benjamin Ahrens |
title |
Two-photon calcium imaging during fictive navigation in virtual environments |
title_short |
Two-photon calcium imaging during fictive navigation in virtual environments |
title_full |
Two-photon calcium imaging during fictive navigation in virtual environments |
title_fullStr |
Two-photon calcium imaging during fictive navigation in virtual environments |
title_full_unstemmed |
Two-photon calcium imaging during fictive navigation in virtual environments |
title_sort |
two-photon calcium imaging during fictive navigation in virtual environments |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neural Circuits |
issn |
1662-5110 |
publishDate |
2013-06-01 |
description |
A full understanding of nervous system function requires recording from large populations of neurons during naturalistic behaviors. Here we enable paralyzed larval zebrafish to fictively navigate two-dimensional virtual environments while we record optically from many neurons with two-photon imaging. Electrical recordings from motor nerves in the tail are decoded into intended forward swims and turns, which are used to update a virtual environment displayed underneath the fish. Several behavioral features - such as turning responses to whole-field motion and dark avoidance - are well-replicated in this virtual setting. We readily observed neuronal populations in the hindbrain with laterally selective responses that correlated with right or left optomotor behavior. We also observed neurons in the habenula, pallium, and midbrain with response properties specific to environmental features. Beyond single-cell correlations, the classification of network activity in such virtual settings promises to reveal principles of brainwide neural dynamics during behavior. |
topic |
Behavior Zebrafish virtual reality motor control two-photon calcium imaging sensorimotor transformations |
url |
http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00104/full |
work_keys_str_mv |
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