Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL.

Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL.

Carbonic anhydrase-8 (CA8) is an intracellular protein that functions as an allosteric inhibitor of inositol trisphosphate receptor-1 (ITPR1) critical to intracellular Ca++ release, synaptic functions and neuronal excitability. We showed previously that murine nociception and analgesic responses are...

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Bibliographic Details
Main Authors: Udita Upadhyay, Gerald Z Zhuang, Luda Diatchenko, Marc Parisien, Yuan Kang, Konstantinos D Sarantopoulos, Eden R Martin, Shad B Smith, William Maixner, Roy C Levitt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008226

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