Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice
The therapeutic goal for the treatment of posttraumatic stress disorder (PTSD) is to promote extinction and to prevent the relapse of fearful memories. Research has identified pharmacological treatments that may regulate the formation and extinction of fear memories, but not many reagents that block...
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doaj-f2364cbb8e0c48d1b0f350bd1c0b379d2020-11-24T21:46:02ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402017-05-01810.3389/fpsyt.2017.00097257114Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in MiceJung-Won Shin0Hyunwoo Park1Hyunwoo Park2Yoonju Cho3Suck Lee4Jiwon Yoon5Sungho Maeng6Sungho Maeng7Sungho Maeng8Department of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South KoreaCenter for Nutraceutical and Pharmaceutical Materials, Myongji University, Yongin, South KoreaDepartment of East-West Medicine, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South KoreaDepartment of East-West Medicine, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South KoreaDepartment of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South KoreaDepartment of East-West Medicine, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South KoreaDepartment of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South KoreaDepartment of East-West Medicine, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South KoreaEast-West Medical Research Institute, Kyung Hee University, Seoul, South KoreaThe therapeutic goal for the treatment of posttraumatic stress disorder (PTSD) is to promote extinction and to prevent the relapse of fearful memories. Research has identified pharmacological treatments that may regulate the formation and extinction of fear memories, but not many reagents that block the relapse of extinguished fear are known. Radix Polygalae (RP) is an Asian herb used for sedation, and its ingredients have anxiolytic and antidepressant properties. As various neurological effects have been identified, we tested whether RP affects the relapse of fear. Freezing in response to a conditioned context and cues was used to measure the effects of RP in mice. In cohort 1 (n = 30), consolidation, extinction, and reinstatement were tested during the course of 18 days of treatment. In cohort 2 (n = 30), consolidation, extinction, and renewal were tested during 10 days of treatment. The consolidation, extinction, reinstatement, and possibly the renewal of context-induced freezing were inhibited due to the administration of RP in animal subjects. However, the effects of RP on the freezing responses of subjects elicited by conditioned auditory cues were less obvious. Because it effectively suppresses the consolidation of fear memories, RP may be used for primary and secondary prevention of symptoms in PTSD patients. Additionally, because it effectively suppresses the reinstatement and renewal of fear memories, RP may be applied for the prevention of fear relapse in PTSD patients who have undergone exposure therapy.http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00097/fullposttraumatic stress disorderconditioned fearRadix Polygalaereinstatementrenewalextinction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jung-Won Shin Hyunwoo Park Hyunwoo Park Yoonju Cho Suck Lee Jiwon Yoon Sungho Maeng Sungho Maeng Sungho Maeng |
spellingShingle |
Jung-Won Shin Hyunwoo Park Hyunwoo Park Yoonju Cho Suck Lee Jiwon Yoon Sungho Maeng Sungho Maeng Sungho Maeng Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice Frontiers in Psychiatry posttraumatic stress disorder conditioned fear Radix Polygalae reinstatement renewal extinction |
author_facet |
Jung-Won Shin Hyunwoo Park Hyunwoo Park Yoonju Cho Suck Lee Jiwon Yoon Sungho Maeng Sungho Maeng Sungho Maeng |
author_sort |
Jung-Won Shin |
title |
Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice |
title_short |
Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice |
title_full |
Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice |
title_fullStr |
Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice |
title_full_unstemmed |
Reduced Consolidation, Reinstatement, and Renewal of Conditioned Fear Memory by Repetitive Treatment of Radix Polygalae in Mice |
title_sort |
reduced consolidation, reinstatement, and renewal of conditioned fear memory by repetitive treatment of radix polygalae in mice |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2017-05-01 |
description |
The therapeutic goal for the treatment of posttraumatic stress disorder (PTSD) is to promote extinction and to prevent the relapse of fearful memories. Research has identified pharmacological treatments that may regulate the formation and extinction of fear memories, but not many reagents that block the relapse of extinguished fear are known. Radix Polygalae (RP) is an Asian herb used for sedation, and its ingredients have anxiolytic and antidepressant properties. As various neurological effects have been identified, we tested whether RP affects the relapse of fear. Freezing in response to a conditioned context and cues was used to measure the effects of RP in mice. In cohort 1 (n = 30), consolidation, extinction, and reinstatement were tested during the course of 18 days of treatment. In cohort 2 (n = 30), consolidation, extinction, and renewal were tested during 10 days of treatment. The consolidation, extinction, reinstatement, and possibly the renewal of context-induced freezing were inhibited due to the administration of RP in animal subjects. However, the effects of RP on the freezing responses of subjects elicited by conditioned auditory cues were less obvious. Because it effectively suppresses the consolidation of fear memories, RP may be used for primary and secondary prevention of symptoms in PTSD patients. Additionally, because it effectively suppresses the reinstatement and renewal of fear memories, RP may be applied for the prevention of fear relapse in PTSD patients who have undergone exposure therapy. |
topic |
posttraumatic stress disorder conditioned fear Radix Polygalae reinstatement renewal extinction |
url |
http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00097/full |
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