Gelatin-Modified Polyurethanes for Soft Tissue Scaffold
Recently, in the field of biomaterials for soft tissue scaffolds, the interest of their modification with natural polymersis growing. Synthetic polymers are often tough, and many of them do not possess fine biocompatibility. On the other hand, natural polymers are biocompatible but weak when used al...
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doaj-f23858bc2b0444c8b329d8218aeab7d42020-11-25T01:09:31ZengHindawi LimitedThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/450132450132Gelatin-Modified Polyurethanes for Soft Tissue ScaffoldJustyna Kucińska-Lipka0Iga Gubańska1Helena Janik2Department of Polymer Technology, Chemical Faculty, Gdansk University of Technology, Narutowicza Street 11/12, 80-233 Gdansk, PolandDepartment of Polymer Technology, Chemical Faculty, Gdansk University of Technology, Narutowicza Street 11/12, 80-233 Gdansk, PolandDepartment of Polymer Technology, Chemical Faculty, Gdansk University of Technology, Narutowicza Street 11/12, 80-233 Gdansk, PolandRecently, in the field of biomaterials for soft tissue scaffolds, the interest of their modification with natural polymersis growing. Synthetic polymers are often tough, and many of them do not possess fine biocompatibility. On the other hand, natural polymers are biocompatible but weak when used alone. The combination of natural and synthetic polymers gives the suitable properties for tissue engineering requirements. In our study, we modified gelatin synthetic polyurethanes prepared from polyester poly(ethylene-butylene adipate) (PEBA), aliphatic 1,6-hexamethylene diisocyanate (HDI), and two different chain extenders 1,4-butanediol (BDO) or 1-ethoxy-2-(2-hydroxyethoxy)ethanol (EHEE). From a chemical point of view, we replaced expensive components for building PU, such as 2,6-diisocyanato methyl caproate (LDI) and 1,4-diisocyanatobutane (BDI), with cost-effective HDI. The gelatin was added in situ (in the first step of synthesis) to polyurethane to increase biocompatibility and biodegradability of the obtained material. It appeared that the obtained gelatin-modified PU foams, in which chain extender was BDO, had enhanced interactions with media and their hydrolytic degradation profile was also improved for tissue engineering application. Furthermore, the gelatin introduction had positive impact on gelatin-modified PU foams by increasing their hemocompatibility.http://dx.doi.org/10.1155/2013/450132 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Justyna Kucińska-Lipka Iga Gubańska Helena Janik |
spellingShingle |
Justyna Kucińska-Lipka Iga Gubańska Helena Janik Gelatin-Modified Polyurethanes for Soft Tissue Scaffold The Scientific World Journal |
author_facet |
Justyna Kucińska-Lipka Iga Gubańska Helena Janik |
author_sort |
Justyna Kucińska-Lipka |
title |
Gelatin-Modified Polyurethanes for Soft Tissue Scaffold |
title_short |
Gelatin-Modified Polyurethanes for Soft Tissue Scaffold |
title_full |
Gelatin-Modified Polyurethanes for Soft Tissue Scaffold |
title_fullStr |
Gelatin-Modified Polyurethanes for Soft Tissue Scaffold |
title_full_unstemmed |
Gelatin-Modified Polyurethanes for Soft Tissue Scaffold |
title_sort |
gelatin-modified polyurethanes for soft tissue scaffold |
publisher |
Hindawi Limited |
series |
The Scientific World Journal |
issn |
1537-744X |
publishDate |
2013-01-01 |
description |
Recently, in the field of biomaterials for soft tissue scaffolds, the interest of their modification with natural polymersis growing. Synthetic polymers are often tough, and many of them do not possess fine biocompatibility. On the other hand, natural polymers are biocompatible but weak when used alone. The combination of natural and synthetic polymers gives the suitable properties for tissue engineering requirements. In our study, we modified gelatin synthetic polyurethanes prepared from polyester poly(ethylene-butylene adipate) (PEBA), aliphatic 1,6-hexamethylene diisocyanate (HDI), and two different chain extenders 1,4-butanediol (BDO) or 1-ethoxy-2-(2-hydroxyethoxy)ethanol (EHEE). From a chemical point of view, we replaced expensive components for building PU, such as 2,6-diisocyanato methyl caproate (LDI) and 1,4-diisocyanatobutane (BDI), with cost-effective HDI. The gelatin was added in situ (in the first step of synthesis) to polyurethane to increase biocompatibility and biodegradability of the obtained material. It appeared that the obtained gelatin-modified PU foams, in which chain extender was BDO, had enhanced interactions with media and their hydrolytic degradation profile was also improved for tissue engineering application. Furthermore, the gelatin introduction had positive impact on gelatin-modified PU foams by increasing their hemocompatibility. |
url |
http://dx.doi.org/10.1155/2013/450132 |
work_keys_str_mv |
AT justynakucinskalipka gelatinmodifiedpolyurethanesforsofttissuescaffold AT igagubanska gelatinmodifiedpolyurethanesforsofttissuescaffold AT helenajanik gelatinmodifiedpolyurethanesforsofttissuescaffold |
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