Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin

Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by CAG repeat expansion in the huntingtin (HTT) gene. Here, we examined the effects of antioxidants on 3-nitropropionic acid (3-NP; a mitochondrial complex II inhibitor)-induced mitochondrial dysfunction and cell death...

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Bibliographic Details
Main Authors: Noria Okada, Tomohiro Yako, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Journal of Pharmacological Sciences
Subjects:
Dynamin-related protein 1
Mitochondrial complex II
Mutant huntingtin
Reactive oxygen species
Striatal neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000876

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