Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial
Abstract Background Loss of upper-extremity motor function is one of the most debilitating deficits following stroke. Two promising treatment approaches, action observation therapy (AOT) and mirror therapy (MT), aim to enhance motor learning and promote neural reorganization in patients through diff...
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doaj-f245647126f745b9b08479fb9a2711632020-11-24T20:56:59ZengBMCTrials1745-62152017-10-011811810.1186/s13063-017-2205-zEffects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trialTsai-yu Shih0Ching-yi Wu1Keh-chung Lin2Chia-hsiung Cheng3Yu-wei Hsieh4Chia-ling Chen5Chih-jou Lai6Chih-chi Chen7Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung UniversityDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung UniversitySchool of Occupational Therapy, College of Medicine, National Taiwan UniversityDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung UniversityDepartment of Occupational Therapy and Graduate Institute of Behavioral Sciences, College of Medicine, Chang Gung UniversityDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial HospitalDepartment of Physical Medicine and Rehabilitation, Taipei Veterans General HospitalDepartment of Physical Medicine and Rehabilitation, Chang Gung Memorial HospitalAbstract Background Loss of upper-extremity motor function is one of the most debilitating deficits following stroke. Two promising treatment approaches, action observation therapy (AOT) and mirror therapy (MT), aim to enhance motor learning and promote neural reorganization in patients through different afferent inputs and patterns of visual feedback. Both approaches involve different patterns of motor observation, imitation, and execution but share some similar neural bases of the mirror neuron system. AOT and MT used in stroke rehabilitation may confer differential benefits and neural activities that remain to be determined. This clinical trial aims to investigate and compare treatment effects and neural activity changes of AOT and MT with those of the control intervention in patients with subacute stroke. Methods/design An estimated total of 90 patients with subacute stroke will be recruited for this study. All participants will be randomly assigned to receive AOT, MT, or control intervention for a 3-week training period (15 sessions). Outcome measurements will be taken at baseline, immediately after treatment, and at the 3-month follow-up. For the magnetoencephalography (MEG) study, we anticipate that we will recruit 12 to 15 patients per group. The primary outcome will be the Fugl-Meyer Assessment score. Secondary outcomes will include the modified Rankin Scale, the Box and Block Test, the ABILHAND questionnaire, the Questionnaire Upon Mental Imagery, the Functional Independence Measure, activity monitors, the Stroke Impact Scale version 3.0, and MEG signals. Discussion This clinical trial will provide scientific evidence of treatment effects on motor, functional outcomes, and neural activity mechanisms after AOT and MT in patients with subacute stroke. Further application and use of AOT and MT may include telerehabilitation or home-based rehabilitation through web-based or video teaching. Trial registration ClinicalTrials.gov, ID: NCT02871700 . Registered on 1 August 2016.http://link.springer.com/article/10.1186/s13063-017-2205-zStrokeNeurorehabilitationAction observationMirror therapyMagnetoencephalography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tsai-yu Shih Ching-yi Wu Keh-chung Lin Chia-hsiung Cheng Yu-wei Hsieh Chia-ling Chen Chih-jou Lai Chih-chi Chen |
spellingShingle |
Tsai-yu Shih Ching-yi Wu Keh-chung Lin Chia-hsiung Cheng Yu-wei Hsieh Chia-ling Chen Chih-jou Lai Chih-chi Chen Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial Trials Stroke Neurorehabilitation Action observation Mirror therapy Magnetoencephalography |
author_facet |
Tsai-yu Shih Ching-yi Wu Keh-chung Lin Chia-hsiung Cheng Yu-wei Hsieh Chia-ling Chen Chih-jou Lai Chih-chi Chen |
author_sort |
Tsai-yu Shih |
title |
Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial |
title_short |
Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial |
title_full |
Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial |
title_fullStr |
Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial |
title_full_unstemmed |
Effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by MEG: study protocol for a randomized controlled trial |
title_sort |
effects of action observation therapy and mirror therapy after stroke on rehabilitation outcomes and neural mechanisms by meg: study protocol for a randomized controlled trial |
publisher |
BMC |
series |
Trials |
issn |
1745-6215 |
publishDate |
2017-10-01 |
description |
Abstract Background Loss of upper-extremity motor function is one of the most debilitating deficits following stroke. Two promising treatment approaches, action observation therapy (AOT) and mirror therapy (MT), aim to enhance motor learning and promote neural reorganization in patients through different afferent inputs and patterns of visual feedback. Both approaches involve different patterns of motor observation, imitation, and execution but share some similar neural bases of the mirror neuron system. AOT and MT used in stroke rehabilitation may confer differential benefits and neural activities that remain to be determined. This clinical trial aims to investigate and compare treatment effects and neural activity changes of AOT and MT with those of the control intervention in patients with subacute stroke. Methods/design An estimated total of 90 patients with subacute stroke will be recruited for this study. All participants will be randomly assigned to receive AOT, MT, or control intervention for a 3-week training period (15 sessions). Outcome measurements will be taken at baseline, immediately after treatment, and at the 3-month follow-up. For the magnetoencephalography (MEG) study, we anticipate that we will recruit 12 to 15 patients per group. The primary outcome will be the Fugl-Meyer Assessment score. Secondary outcomes will include the modified Rankin Scale, the Box and Block Test, the ABILHAND questionnaire, the Questionnaire Upon Mental Imagery, the Functional Independence Measure, activity monitors, the Stroke Impact Scale version 3.0, and MEG signals. Discussion This clinical trial will provide scientific evidence of treatment effects on motor, functional outcomes, and neural activity mechanisms after AOT and MT in patients with subacute stroke. Further application and use of AOT and MT may include telerehabilitation or home-based rehabilitation through web-based or video teaching. Trial registration ClinicalTrials.gov, ID: NCT02871700 . Registered on 1 August 2016. |
topic |
Stroke Neurorehabilitation Action observation Mirror therapy Magnetoencephalography |
url |
http://link.springer.com/article/10.1186/s13063-017-2205-z |
work_keys_str_mv |
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