Phenotype switching in melanoma: implications for progression and therapy

Phenotype switching in melanoma: implications for progression and therapy

Epithelial-mesenchymal-transition (EMT) is a key process associated with theprogression of epithelial cancers to metastatic disease. In melanoma, a similar processof phenotype switching has been reported and EMT-related genes have beenimplicated in promotion to a metastatic state. This review examin...

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Bibliographic Details
Main Authors: Frederic Zhentao Li, Amardeep Singh Dhillon, Robin eAnderson, Grant eMcArthur, Petranel Theresa Ferrao
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Oncology
Subjects:
Drug Resistance
Melanoma
metastasis
targeted therapy
BRAF
EMT
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00031/full

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