Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody

Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody

Cluster of differentiation 47 (CD47) is a widely expressed self‐protection transmembrane protein that functions as a critical negative regulator to induce macrophage‐mediated phagocytosis. Overexpression of CD47 enables cancer cells to escape immune surveillance and destruction by phagocytes both in...

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Bibliographic Details
Main Authors: Zhiqiang Xu, Jing Gao, Jingyun Yao, Teddy Yang, Dongxu Wang, Chaohui Dai, Yu Ding
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:FEBS Open Bio
Subjects:
4D10
antibody
CD47
haemagglutination
phagocytosis
SIRPα
Online Access:https://doi.org/10.1002/2211-5463.13084

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