Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency
<p>Abstract</p> <p>Background</p> <p>Treatment of tumors with macromolecular toxins directed to cytoplasmic targets requires selective endocytosis followed by release of intact toxin from the endosomal/lysosomal compartment. The latter step remains a particular challeng...
Main Authors: | Howell Stephen B, Manorek Gerald, Lin Xinjian, Yuan Xiaoqin |
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Format: | Article |
Language: | English |
Published: |
BMC
2011-02-01
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Series: | BMC Cancer |
Online Access: | http://www.biomedcentral.com/1471-2407/11/61 |
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