Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored the critical role of the competitive endogenous RNA (ceRNA) regulatory networks among various human cancers. However, the complexity and behavior characterist...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Molecular Therapy: Nucleic Acids |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253120303978 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yi Shi Dan-Dan Zhang Ji-Bin Liu Xiao-Li Yang Rui Xin Cheng-You Jia Hui-Min Wang Gai-Xia Lu Pei-Yao Wang Yu Liu Zi-Jin Li Jing Deng Qin-Lu Lin Liang Ma Shan-Shan Feng Xiao-Qi Chen Xiang-Min Zheng Ya-Fu Zhou Yong-Jun Hu Hua-Qun Yin Lin-Lin Tian Li-Peng Gu Zhong-Wei Lv Fei Yu Wen Li Yu-Shui Ma Fu Da |
| spellingShingle |
Yi Shi Dan-Dan Zhang Ji-Bin Liu Xiao-Li Yang Rui Xin Cheng-You Jia Hui-Min Wang Gai-Xia Lu Pei-Yao Wang Yu Liu Zi-Jin Li Jing Deng Qin-Lu Lin Liang Ma Shan-Shan Feng Xiao-Qi Chen Xiang-Min Zheng Ya-Fu Zhou Yong-Jun Hu Hua-Qun Yin Lin-Lin Tian Li-Peng Gu Zhong-Wei Lv Fei Yu Wen Li Yu-Shui Ma Fu Da Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma Molecular Therapy: Nucleic Acids HCC ceRNA network DLEU2L/TAOK1 axis prognosis |
| author_facet |
Yi Shi Dan-Dan Zhang Ji-Bin Liu Xiao-Li Yang Rui Xin Cheng-You Jia Hui-Min Wang Gai-Xia Lu Pei-Yao Wang Yu Liu Zi-Jin Li Jing Deng Qin-Lu Lin Liang Ma Shan-Shan Feng Xiao-Qi Chen Xiang-Min Zheng Ya-Fu Zhou Yong-Jun Hu Hua-Qun Yin Lin-Lin Tian Li-Peng Gu Zhong-Wei Lv Fei Yu Wen Li Yu-Shui Ma Fu Da |
| author_sort |
Yi Shi |
| title |
Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma |
| title_short |
Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma |
| title_full |
Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma |
| title_fullStr |
Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma |
| title_full_unstemmed |
Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinoma |
| title_sort |
comprehensive analysis to identify dleu2l/taok1 axis as a prognostic biomarker in hepatocellular carcinoma |
| publisher |
Elsevier |
| series |
Molecular Therapy: Nucleic Acids |
| issn |
2162-2531 |
| publishDate |
2021-03-01 |
| description |
Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored the critical role of the competitive endogenous RNA (ceRNA) regulatory networks among various human cancers. However, the complexity and behavior characteristics of the ceRNA network in HCC were still unclear. In this study, we aimed to clarify a phosphatase and tensin homolog (PTEN)-related ceRNA regulatory network and identify potential prognostic markers associated with HCC. The expression profiles of three RNAs (long non-coding RNAs [lncRNAs], microRNAs [miRNAs], and mRNAs) were extracted from The Cancer Genome Atlas (TCGA) database. The DLEU2L-hsa-miR-100-5p/ hsa-miR-99a-5p-TAOK1 ceRNA network related to the prognosis of HCC was obtained by performing bioinformatics analysis. Importantly, we identified the DLEU2L/TAOK1 axis in the ceRNA by using correlation analysis, and it appeared to become a clinical prognostic model by Cox regression analysis. Furthermore, methylation analyses suggested that the abnormal upregulation of the DLEU2L/TAOK1 axis likely resulted from hypomethylation, and immune infiltration analysis showed that the DLEU2L/TAOK1 axis may have an impact on the changes in the tumor immune microenvironment and the development of HCC. In summary, the current study constructing a ceRNA-based DLEU2L/TAOK1 axis might be a novel important prognostic factor associated with the diagnosis and prognosis of HCC. |
| topic |
HCC ceRNA network DLEU2L/TAOK1 axis prognosis |
| url |
http://www.sciencedirect.com/science/article/pii/S2162253120303978 |
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doaj-f2631c2bd35e48c7b7f93624a43cc93f2021-03-07T04:27:57ZengElsevierMolecular Therapy: Nucleic Acids2162-25312021-03-0123702718Comprehensive analysis to identify DLEU2L/TAOK1 axis as a prognostic biomarker in hepatocellular carcinomaYi Shi0Dan-Dan Zhang1Ji-Bin Liu2Xiao-Li Yang3Rui Xin4Cheng-You Jia5Hui-Min Wang6Gai-Xia Lu7Pei-Yao Wang8Yu Liu9Zi-Jin Li10Jing Deng11Qin-Lu Lin12Liang Ma13Shan-Shan Feng14Xiao-Qi Chen15Xiang-Min Zheng16Ya-Fu Zhou17Yong-Jun Hu18Hua-Qun Yin19Lin-Lin Tian20Li-Peng Gu21Zhong-Wei Lv22Fei Yu23Wen Li24Yu-Shui Ma25Fu Da26National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; Cancer Institute, Nantong Tumor Hospital, Nantong 226631, China; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, ChinaDepartment of Pathology, Shihezi University School of Medicine, Shihezi 832002, Xinjiang, China; Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaCancer Institute, Nantong Tumor Hospital, Nantong 226631, ChinaCentral Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaCentral Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaCentral Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaCentral Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaNational Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, ChinaNational Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, ChinaNational Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, ChinaNational Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, ChinaCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, ChinaCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, ChinaNational Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, ChinaCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, ChinaDepartment of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan, ChinaDepartment of Cardiology, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan, ChinaSchool of Resource Processing and Bioengineering, Central South University, Changsha 410083, Hunan, ChinaCentral Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaCentral Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaNational Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China; Corresponding author: Wen Li, PhD, National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, 498 South Shaoshan Road, Changsha 410004, Hunan, China.Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China; Department of Pancreatic and Hepatobiliary Surgery, Cancer Hospital, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China; Corresponding author: Yu-Shui Ma, PhD, Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 36 Yunxin Road, Shanghai 200072, China.National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China; Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China; Corresponding author: Da Fu, PhD, Central Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 36 Yunxin Road, Shanghai 200072, China.Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored the critical role of the competitive endogenous RNA (ceRNA) regulatory networks among various human cancers. However, the complexity and behavior characteristics of the ceRNA network in HCC were still unclear. In this study, we aimed to clarify a phosphatase and tensin homolog (PTEN)-related ceRNA regulatory network and identify potential prognostic markers associated with HCC. The expression profiles of three RNAs (long non-coding RNAs [lncRNAs], microRNAs [miRNAs], and mRNAs) were extracted from The Cancer Genome Atlas (TCGA) database. The DLEU2L-hsa-miR-100-5p/ hsa-miR-99a-5p-TAOK1 ceRNA network related to the prognosis of HCC was obtained by performing bioinformatics analysis. Importantly, we identified the DLEU2L/TAOK1 axis in the ceRNA by using correlation analysis, and it appeared to become a clinical prognostic model by Cox regression analysis. Furthermore, methylation analyses suggested that the abnormal upregulation of the DLEU2L/TAOK1 axis likely resulted from hypomethylation, and immune infiltration analysis showed that the DLEU2L/TAOK1 axis may have an impact on the changes in the tumor immune microenvironment and the development of HCC. In summary, the current study constructing a ceRNA-based DLEU2L/TAOK1 axis might be a novel important prognostic factor associated with the diagnosis and prognosis of HCC.http://www.sciencedirect.com/science/article/pii/S2162253120303978HCCceRNA networkDLEU2L/TAOK1 axisprognosis |