Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors
The acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pH<sub>e</sub>), which is a hallmark of the tumor microenvironment in solid tumor...
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doaj-f27498d7333a4abe9da6869837a91f792021-06-30T23:09:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226024602410.3390/ijms22116024Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin TumorsKirsten Ackermann0Susanne Wallner1Christoph Brochhausen2Stephan Schreml3Department of Dermatology, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment of Dermatology, University Medical Center Regensburg, 93053 Regensburg, GermanyInstitute of Pathology, University of Regensburg, 93053 Regensburg, GermanyDepartment of Dermatology, University Medical Center Regensburg, 93053 Regensburg, GermanyThe acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pH<sub>e</sub>), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this study, we investigated the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and in nevus cell nevi (NCN). We conducted immunohistochemistry using paraffin-embedded tissue samples from patients and found that most skin tumors express ASIC1/2 and TRPV1/4. Striking results were that BCCs are often negative for ASIC2, while nearly all SCCs express this marker. Epidermal MM sometimes seem to lack ASIC1 in contrast to NCN. Dermal portions of MM show strong expression of TRPV1 more frequently than dermal NCN portions. Some NCN show a decreasing ASIC1/2 expression in deeper dermal tumor tissue, while MM seem to not lose ASIC1/2 in deeper dermal portions. ASIC1, ASIC2, TRPV1 and TRPV4 in skin tumors might be involved in tumor progression, thus being potential diagnostic and therapeutic targets.https://www.mdpi.com/1422-0067/22/11/6024melanomasquamous cell carcinomabasal cell carcinomaproton-sensitive ion channels |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kirsten Ackermann Susanne Wallner Christoph Brochhausen Stephan Schreml |
spellingShingle |
Kirsten Ackermann Susanne Wallner Christoph Brochhausen Stephan Schreml Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors International Journal of Molecular Sciences melanoma squamous cell carcinoma basal cell carcinoma proton-sensitive ion channels |
author_facet |
Kirsten Ackermann Susanne Wallner Christoph Brochhausen Stephan Schreml |
author_sort |
Kirsten Ackermann |
title |
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors |
title_short |
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors |
title_full |
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors |
title_fullStr |
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors |
title_full_unstemmed |
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors |
title_sort |
expression profiles of asic1/2 and trpv1/4 in common skin tumors |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-06-01 |
description |
The acid-sensing ion channels ASIC1 and ASIC2, as well as the transient receptor potential vanilloid channels TRPV1 and TRPV4, are proton-gated cation channels that can be activated by low extracellular pH (pH<sub>e</sub>), which is a hallmark of the tumor microenvironment in solid tumors. However, the role of these channels in the development of skin tumors is still unclear. In this study, we investigated the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma (MM), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and in nevus cell nevi (NCN). We conducted immunohistochemistry using paraffin-embedded tissue samples from patients and found that most skin tumors express ASIC1/2 and TRPV1/4. Striking results were that BCCs are often negative for ASIC2, while nearly all SCCs express this marker. Epidermal MM sometimes seem to lack ASIC1 in contrast to NCN. Dermal portions of MM show strong expression of TRPV1 more frequently than dermal NCN portions. Some NCN show a decreasing ASIC1/2 expression in deeper dermal tumor tissue, while MM seem to not lose ASIC1/2 in deeper dermal portions. ASIC1, ASIC2, TRPV1 and TRPV4 in skin tumors might be involved in tumor progression, thus being potential diagnostic and therapeutic targets. |
topic |
melanoma squamous cell carcinoma basal cell carcinoma proton-sensitive ion channels |
url |
https://www.mdpi.com/1422-0067/22/11/6024 |
work_keys_str_mv |
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