THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSIS
Aim. To assess the concentrations of osteoprotegerin (OPG) and soluble ligand of the receptor of transcription activator factor kappa-B (sRANKL) in the blood serum of patients with various grade of aortic stenosis (AS) severity.Material and methods. Totally, 247 AS patients studied of various grade:...
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doaj-f2796dc477ec43acb26548b2706a1ccc2021-07-28T14:02:31Zrus«FIRMA «SILICEA» LLC Российский кардиологический журнал1560-40712618-76202018-03-0102394310.15829/1560-4071-2018-2-39-432336THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSISO. B. Irtyuga0E. V. Zhiduleva1P. М. Murtazalieva2Yu. S. Sibagatullina3L. P. Kruk4V. N. Solntsev5А. А. Shishkova6А. B. Malashicheva7О. М. Moiseeva8Federal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthSaint-Petersburg State UniversityFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of HealthFederal Almazov North-West Medical Research Centre of the Ministry of Health; Saint-Petersburg State UniversityFederal Almazov North-West Medical Research Centre of the Ministry of HealthAim. To assess the concentrations of osteoprotegerin (OPG) and soluble ligand of the receptor of transcription activator factor kappa-B (sRANKL) in the blood serum of patients with various grade of aortic stenosis (AS) severity.Material and methods. Totally, 247 AS patients studied of various grade: 46 — mild, 53 — moderate and 149 — severe. Of those 132 (53%) with bicuspid aortic valve (BAV) and 115 (47%) with tricuspid (TAV). Controls were 58 patients with no valvular pathology or coronary heart disease. All patients underwent lipid profile measurement, serum C-reactive protein (CRP) and OPG, sRANKL.Results. In all studied groups of AS patients there was increased level of sRANKL in blood serum, comparing to controls (BAV =0,37 [0,32;0,53] pM/L, TAV =0,38 [0,33;0,50] pM/L, controls 0,30 [0,21;0,39] pM/L; р<0,0001). Concentration of OPG was increased only in TAV: 6,99 [5,19;9,90] pM/L; comparing to 5,23 [4,30;7,09] pM/L in BAV (р=0,0008). A hypothesis proposed that OPG concentration increase is compensatory and takes place as a response to the increase of the concentration or due to loss of sensitivity to sRANKL.Conclusion. Development of AS is related to disorders in OPG/RANKL system, and these revealed changes might have significant diagnostic and predictive value, especially in TAV.https://russjcardiol.elpub.ru/jour/article/view/2674aortic stenosiscalcinosisbiomarkersosteoprotegerinsrankl |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
O. B. Irtyuga E. V. Zhiduleva P. М. Murtazalieva Yu. S. Sibagatullina L. P. Kruk V. N. Solntsev А. А. Shishkova А. B. Malashicheva О. М. Moiseeva |
spellingShingle |
O. B. Irtyuga E. V. Zhiduleva P. М. Murtazalieva Yu. S. Sibagatullina L. P. Kruk V. N. Solntsev А. А. Shishkova А. B. Malashicheva О. М. Moiseeva THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSIS Российский кардиологический журнал aortic stenosis calcinosis biomarkers osteoprotegerin srankl |
author_facet |
O. B. Irtyuga E. V. Zhiduleva P. М. Murtazalieva Yu. S. Sibagatullina L. P. Kruk V. N. Solntsev А. А. Shishkova А. B. Malashicheva О. М. Moiseeva |
author_sort |
O. B. Irtyuga |
title |
THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSIS |
title_short |
THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSIS |
title_full |
THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSIS |
title_fullStr |
THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSIS |
title_full_unstemmed |
THE ROLE OF OSTEOPROTEGERIN SYSTEM /RANKL/RANK IN PATHOGENESIS OF AORTIC STENOSIS |
title_sort |
role of osteoprotegerin system /rankl/rank in pathogenesis of aortic stenosis |
publisher |
«FIRMA «SILICEA» LLC |
series |
Российский кардиологический журнал |
issn |
1560-4071 2618-7620 |
publishDate |
2018-03-01 |
description |
Aim. To assess the concentrations of osteoprotegerin (OPG) and soluble ligand of the receptor of transcription activator factor kappa-B (sRANKL) in the blood serum of patients with various grade of aortic stenosis (AS) severity.Material and methods. Totally, 247 AS patients studied of various grade: 46 — mild, 53 — moderate and 149 — severe. Of those 132 (53%) with bicuspid aortic valve (BAV) and 115 (47%) with tricuspid (TAV). Controls were 58 patients with no valvular pathology or coronary heart disease. All patients underwent lipid profile measurement, serum C-reactive protein (CRP) and OPG, sRANKL.Results. In all studied groups of AS patients there was increased level of sRANKL in blood serum, comparing to controls (BAV =0,37 [0,32;0,53] pM/L, TAV =0,38 [0,33;0,50] pM/L, controls 0,30 [0,21;0,39] pM/L; р<0,0001). Concentration of OPG was increased only in TAV: 6,99 [5,19;9,90] pM/L; comparing to 5,23 [4,30;7,09] pM/L in BAV (р=0,0008). A hypothesis proposed that OPG concentration increase is compensatory and takes place as a response to the increase of the concentration or due to loss of sensitivity to sRANKL.Conclusion. Development of AS is related to disorders in OPG/RANKL system, and these revealed changes might have significant diagnostic and predictive value, especially in TAV. |
topic |
aortic stenosis calcinosis biomarkers osteoprotegerin srankl |
url |
https://russjcardiol.elpub.ru/jour/article/view/2674 |
work_keys_str_mv |
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