Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
Natriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors...
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2018-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04891-5 |
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doaj-f29494c168df440eb80c83114574bf1a2021-05-11T10:00:53ZengNature Publishing GroupNature Communications2041-17232018-06-01911910.1038/s41467-018-04891-5Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMPHariharan Subramanian0Alexander Froese1Peter Jönsson2Hannes Schmidt3Julia Gorelik4Viacheslav O. Nikolaev5Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-EppendorfInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-EppendorfDepartment of Chemistry, Lund UniversityInterfaculty Institute of Biochemistry, University of TübingenMyocardial Function, National Heart and Lung Institute, ICTEM, Hammersmith Hospital, Imperial College LondonInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-EppendorfNatriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors within the heart.https://doi.org/10.1038/s41467-018-04891-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hariharan Subramanian Alexander Froese Peter Jönsson Hannes Schmidt Julia Gorelik Viacheslav O. Nikolaev |
spellingShingle |
Hariharan Subramanian Alexander Froese Peter Jönsson Hannes Schmidt Julia Gorelik Viacheslav O. Nikolaev Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP Nature Communications |
author_facet |
Hariharan Subramanian Alexander Froese Peter Jönsson Hannes Schmidt Julia Gorelik Viacheslav O. Nikolaev |
author_sort |
Hariharan Subramanian |
title |
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP |
title_short |
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP |
title_full |
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP |
title_fullStr |
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP |
title_full_unstemmed |
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP |
title_sort |
distinct submembrane localisation compartmentalises cardiac npr1 and npr2 signalling to cgmp |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-06-01 |
description |
Natriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors within the heart. |
url |
https://doi.org/10.1038/s41467-018-04891-5 |
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