Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP

Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP

Natriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors...

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Main Authors: Hariharan Subramanian, Alexander Froese, Peter Jönsson, Hannes Schmidt, Julia Gorelik, Viacheslav O. Nikolaev
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04891-5
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spelling doaj-f29494c168df440eb80c83114574bf1a2021-05-11T10:00:53ZengNature Publishing GroupNature Communications2041-17232018-06-01911910.1038/s41467-018-04891-5Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMPHariharan Subramanian0Alexander Froese1Peter Jönsson2Hannes Schmidt3Julia Gorelik4Viacheslav O. Nikolaev5Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-EppendorfInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-EppendorfDepartment of Chemistry, Lund UniversityInterfaculty Institute of Biochemistry, University of TübingenMyocardial Function, National Heart and Lung Institute, ICTEM, Hammersmith Hospital, Imperial College LondonInstitute of Experimental Cardiovascular Research, University Medical Center Hamburg-EppendorfNatriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors within the heart.https://doi.org/10.1038/s41467-018-04891-5
collection DOAJ
language English
format Article
sources DOAJ
author Hariharan Subramanian
Alexander Froese
Peter Jönsson
Hannes Schmidt
Julia Gorelik
Viacheslav O. Nikolaev
spellingShingle Hariharan Subramanian
Alexander Froese
Peter Jönsson
Hannes Schmidt
Julia Gorelik
Viacheslav O. Nikolaev
Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
Nature Communications
author_facet Hariharan Subramanian
Alexander Froese
Peter Jönsson
Hannes Schmidt
Julia Gorelik
Viacheslav O. Nikolaev
author_sort Hariharan Subramanian
title Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
title_short Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
title_full Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
title_fullStr Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
title_full_unstemmed Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP
title_sort distinct submembrane localisation compartmentalises cardiac npr1 and npr2 signalling to cgmp
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-06-01
description Natriuretic peptides (NPs) are important hormones that regulate cardiovascular physiology by increasing cGMP levels in cardiomyocytes. Here the authors use scanning ion conductance microscopy and a cGMP FRET sensor to identify a differential localisation pattern for the natriuretic peptide receptors within the heart.
url https://doi.org/10.1038/s41467-018-04891-5
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