Effect of lipid-lowering anticoagulant therapy combined with compound Danshen dropping pill on the endothelial function and serum biochemical indexes in patients with hypertension and carotid atherosclerosis

• Main Author: Yan-Feng Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Carotid atherosclerosis Compound danshen dropping pill Endothelial function Adipocytokine
• Online Access: http://www.hnykdxxb.com/PDF/201707/10.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of lipid-lowering anticoagulant therapy combined with compound Danshen dropping pill on the endothelial function and serum biochemical indexes in patients with hypertension and carotid atherosclerosis. Methods: 98 patients with hypertension and carotid atherosclerosis treated in our hospital between June 2014 and July 2016 were selected as the research subjects and randomly divided into the research group who received lipid-lowering anticoagulant therapy combined with compound Danshen and the control group who received conventional lipid-lowering anticoagulant therapy. After 4 weeks of treatment, endothelial injury indexes and lipid metabolism indexes in serum were determined. Results: After 4 weeks of treatment, serum endothelin-1 (ET-1), thromboxane B2 (TXB2), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), oxidized low density lipoprotein (ox-LDL), lipoprotein (a) [Lp(a)], leptin, resistin and chemerin levels of research group were significantly lower than those of control group (P<0.05) while nitric oxide (NO), 6-Keto-PGF1α, high-density lipoprotein cholesterol (HDL-C), adiponectin and visfatin levels were significantly higher than those of control group (P<0.05). Conclusion: Lipidlowering anticoagulant therapy combined with compound Danshen dropping pill can improve the endothelial function and lipid metabolism in patients with hypertension and carotid atherosclerosis.