Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review

Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review

E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium...

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Bibliographic Details
Main Authors: Giovanni Corso, Giacomo Montagna, Joana Figueiredo, Carlo La Vecchia, Uberto Fumagalli Romario, Maria Sofia Fernandes, Susana Seixas, Franco Roviello, Cristina Trovato, Elena Guerini-Rocco, Nicola Fusco, Gabriella Pravettoni, Serena Petrocchi, Anna Rotili, Giulia Massari, Francesca Magnoni, Francesca De Lorenzi, Manuela Bottoni, Viviana Galimberti, João Miguel Sanches, Mariarosaria Calvello, Raquel Seruca, Bernardo Bonanni
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
gastric cancer
breast cancer
E-cadherin
CDH1 gene
germline mutations
hereditary syndrome
Online Access:https://www.mdpi.com/2072-6694/12/6/1598

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