Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice
Purpose Microwave ablation (MWA) provides an effective treatment of lung and liver tumors but suffers from a lack of reproducibility of ablation size among currently available technologies. In-vitro evaluations are far removed from clinical practices because of uninfused tissue. This study is in-viv...
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doaj-f2ad56ea8dcc4777a6a35666a3350b7a2021-08-09T15:50:04ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572021-01-013811140114810.1080/02656736.2021.19618831961883Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practicePaul Habert0Mathieu Di Bisceglie1Jean-François Hak2Pauline Brige3Sophie Chopinet4Julien Mancini5Axel Bartoli6Vincent Vidal7Charles Roux8Lambros Tselikas9Thierry De Baere10Jean-Yves Gaubert11Department of Interventional Imaging, Assistance Publique Hopitaux de MarseilleDepartment of Interventional Imaging, Assistance Publique Hopitaux de MarseilleDepartment of Interventional Imaging, Assistance Publique Hopitaux de MarseilleAix Marseille University, LIIEAix Marseille University, LIIEBiostatistics Department, BIOSTIC, Aix Marseille University, APHM, INSERM, IRD, SESSTIM, ISSPAM, Hop TimoneDepartment of Interventional Imaging, Assistance Publique Hopitaux de MarseilleDepartment of Interventional Imaging, Assistance Publique Hopitaux de MarseilleDepartement d’Anesthesie, Chirurgie et Interventionel, Gustave RoussyDepartement d’Anesthesie, Chirurgie et Interventionel, Gustave RoussyDepartement d’Anesthesie, Chirurgie et Interventionel, Gustave RoussyDepartment of Interventional Imaging, Assistance Publique Hopitaux de MarseillePurpose Microwave ablation (MWA) provides an effective treatment of lung and liver tumors but suffers from a lack of reproducibility of ablation size among currently available technologies. In-vitro evaluations are far removed from clinical practices because of uninfused tissue. This study is in-vivo preclinical testing of a new MWA system on swine lungs and liver. Materials and methods All ablations were performed under CT guidance and multiple algorithms were tested with a power of 50, 75, and 100 W for durations of 3, 5, 8, 10, and 15 min. A 3 D-evaluation of the ablation zone was carried out using enhanced-CT. The sphericity index, coefficients of variation, and energy efficiency (which corresponds to the volume yield according to the power supplied) were calculated. Results Fifty liver and 48 lung ablations were performed in 17 swine. The sphericity index varies from 0.50 to 0.80 for liver ablations and from 0.40 to 0.69 for lung ablations. The coefficient of variation was below 15% for 4/5 and 4/8 protocols for lung and liver ablations, respectively. The energy efficiency seems to decrease with the duration of the ablation from 0.60 × 10−3 cm3/J (75 W, 3 min) to 0.26 × 10−3 cm3/J (100 W, 15 min) in the liver and from 0.57 × 10−3 cm3/J (50 W, 10 min) to 0.42 × 10−3 cm3/J (100 W, 12 min) in the lungs. Conclusion A shorter treatment time provides the best energy efficiency, and the best reproducibility is obtained for a 10 min treatment duration. The system tested provides an interesting reproducibility in both lung and liver measurements. Our results may help interventional radiologists in the optimal selection of treatment parameters.http://dx.doi.org/10.1080/02656736.2021.1961883microwave ablationlung ablationliver ablationin vivo experimentsswine model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paul Habert Mathieu Di Bisceglie Jean-François Hak Pauline Brige Sophie Chopinet Julien Mancini Axel Bartoli Vincent Vidal Charles Roux Lambros Tselikas Thierry De Baere Jean-Yves Gaubert |
spellingShingle |
Paul Habert Mathieu Di Bisceglie Jean-François Hak Pauline Brige Sophie Chopinet Julien Mancini Axel Bartoli Vincent Vidal Charles Roux Lambros Tselikas Thierry De Baere Jean-Yves Gaubert Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice International Journal of Hyperthermia microwave ablation lung ablation liver ablation in vivo experiments swine model |
author_facet |
Paul Habert Mathieu Di Bisceglie Jean-François Hak Pauline Brige Sophie Chopinet Julien Mancini Axel Bartoli Vincent Vidal Charles Roux Lambros Tselikas Thierry De Baere Jean-Yves Gaubert |
author_sort |
Paul Habert |
title |
Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice |
title_short |
Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice |
title_full |
Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice |
title_fullStr |
Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice |
title_full_unstemmed |
Percutaneous lung and liver CT-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice |
title_sort |
percutaneous lung and liver ct-guided ablation on swine model using microwave ablation to determine ablation size for clinical practice |
publisher |
Taylor & Francis Group |
series |
International Journal of Hyperthermia |
issn |
0265-6736 1464-5157 |
publishDate |
2021-01-01 |
description |
Purpose Microwave ablation (MWA) provides an effective treatment of lung and liver tumors but suffers from a lack of reproducibility of ablation size among currently available technologies. In-vitro evaluations are far removed from clinical practices because of uninfused tissue. This study is in-vivo preclinical testing of a new MWA system on swine lungs and liver. Materials and methods All ablations were performed under CT guidance and multiple algorithms were tested with a power of 50, 75, and 100 W for durations of 3, 5, 8, 10, and 15 min. A 3 D-evaluation of the ablation zone was carried out using enhanced-CT. The sphericity index, coefficients of variation, and energy efficiency (which corresponds to the volume yield according to the power supplied) were calculated. Results Fifty liver and 48 lung ablations were performed in 17 swine. The sphericity index varies from 0.50 to 0.80 for liver ablations and from 0.40 to 0.69 for lung ablations. The coefficient of variation was below 15% for 4/5 and 4/8 protocols for lung and liver ablations, respectively. The energy efficiency seems to decrease with the duration of the ablation from 0.60 × 10−3 cm3/J (75 W, 3 min) to 0.26 × 10−3 cm3/J (100 W, 15 min) in the liver and from 0.57 × 10−3 cm3/J (50 W, 10 min) to 0.42 × 10−3 cm3/J (100 W, 12 min) in the lungs. Conclusion A shorter treatment time provides the best energy efficiency, and the best reproducibility is obtained for a 10 min treatment duration. The system tested provides an interesting reproducibility in both lung and liver measurements. Our results may help interventional radiologists in the optimal selection of treatment parameters. |
topic |
microwave ablation lung ablation liver ablation in vivo experiments swine model |
url |
http://dx.doi.org/10.1080/02656736.2021.1961883 |
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