Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcript...
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2017-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00398-7 |
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doaj-f2aea08fe9e3479693ecf280fdffb6692021-01-31T12:39:52ZengNature Publishing GroupNature Communications2041-17232017-08-018111210.1038/s41467-017-00398-7Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activityAlessia Loffreda0Emanuela Jacchetti1Sofia Antunes2Paolo Rainone3Tiziana Daniele4Tatsuya Morisaki5Marco E. Bianchi6Carlo Tacchetti7Davide Mazza8Istituto Scientifico Ospedale San Raffaele, Centro di Imaging SperimentaleIstituto Scientifico Ospedale San Raffaele, Centro di Imaging SperimentaleIstituto Scientifico Ospedale San Raffaele, Centro di Imaging SperimentaleIstituto Scientifico Ospedale San Raffaele, Centro di Imaging SperimentaleIstituto Scientifico Ospedale San Raffaele, Centro di Imaging SperimentaleFluorescence Imaging Group, National Cancer Institute, NIHIstituto Scientifico Ospedale San Raffaele, Chromatin Dynamics UnitIstituto Scientifico Ospedale San Raffaele, Centro di Imaging SperimentaleIstituto Scientifico Ospedale San Raffaele, Centro di Imaging SperimentaleBoth transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity.https://doi.org/10.1038/s41467-017-00398-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alessia Loffreda Emanuela Jacchetti Sofia Antunes Paolo Rainone Tiziana Daniele Tatsuya Morisaki Marco E. Bianchi Carlo Tacchetti Davide Mazza |
spellingShingle |
Alessia Loffreda Emanuela Jacchetti Sofia Antunes Paolo Rainone Tiziana Daniele Tatsuya Morisaki Marco E. Bianchi Carlo Tacchetti Davide Mazza Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity Nature Communications |
author_facet |
Alessia Loffreda Emanuela Jacchetti Sofia Antunes Paolo Rainone Tiziana Daniele Tatsuya Morisaki Marco E. Bianchi Carlo Tacchetti Davide Mazza |
author_sort |
Alessia Loffreda |
title |
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity |
title_short |
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity |
title_full |
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity |
title_fullStr |
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity |
title_full_unstemmed |
Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity |
title_sort |
live-cell p53 single-molecule binding is modulated by c-terminal acetylation and correlates with transcriptional activity |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-08-01 |
description |
Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity. |
url |
https://doi.org/10.1038/s41467-017-00398-7 |
work_keys_str_mv |
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