Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcript...
Main Authors: | Alessia Loffreda, Emanuela Jacchetti, Sofia Antunes, Paolo Rainone, Tiziana Daniele, Tatsuya Morisaki, Marco E. Bianchi, Carlo Tacchetti, Davide Mazza |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00398-7 |
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