Assessment of Potential Prognostic Value of Peroxiredoxin 1 in Oral Squamous Cell Carcinoma

• Main Authors: Shen Y, Xu H, Li L, Lu Y, Zhang M, Huang X, Tang X
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-07-01
• Series: Cancer Management and Research
• Subjects: peroxiredoxin 1; oral squamous cell carcinoma; lymph node metastasis; prognosis; nomogram
• Online Access: https://www.dovepress.com/assessment-of-potential-prognostic-value-of-peroxiredoxin-1-in-oral-sq-peer-reviewed-fulltext-article-CMAR

Yajun Shen,1 Haoyue Xu,2 Lingyu Li,1 Yunping Lu,1 Min Zhang,1 Xin Huang,2 Xiaofei Tang1 1Beijing Institute of Dental Research, Beijing Key Laboratory, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing, 100050, People’s Republic of China; 2Department of Oral and Maxillofacial Surgery, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, Beijing, 100050, People’s Republic of ChinaCorrespondence: Xiaofei TangDivision of Oral Pathology, Beijing Institute of Dental Research, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, No. 4 Tiantanxili, Dongcheng District, Beijing, 100050, People’s Republic of ChinaTel [phone]Fax [phone]Email [e-mail] HuangDepartment of Oral and Maxillofacial Surgery, Beijing Stomatological Hospital & School of Stomatology, Capital Medical University, No. 4 Tiantan Xili, Dongcheng District, Beijing, 100050, People’s Republic of ChinaEmail [e-mail]: The role of the peroxiredoxin (PRDX) family in oral squamous cell carcinoma (OSCC) remains unclear. This study aimed to investigate the expression of PRDXs and their effects on the prognosis in OSCC.Methods: The expression of PRDXs and their effects on prognosis were analysed in 216 OSCC samples from The Cancer Genome Atlas (TCGA) database. OSCC tissues and adjacent noncancerous tissues (ANTs) were obtained from 68 clinical patients. Quantitative real-time (qRT)-PCR, Western blot, and immunohistochemical (IHC) staining were used to verify the relationship between the expression level of PRDX1 and different clinical features. Gene set enrichment analysis (GSEA) was used to examine the molecular mechanism of PRDX1 in OSCC.Results: PRDX1 was found to be the only gene in PRDX family that highly expressed in OSCC samples and affected the prognosis of patients with OSCC. PRDX1 expression was significantly related to tumor stage, lymphatic metastasis, and pathological grade. A nomogram consisting of tumor stage, N stage, and PRDX1 level was constructed. GSEA showed that high expression of PRDX1 involved many cancer-related molecular functions and signaling pathways.Conclusion: PRDX1 may play an important role in the occurrence and development of OSCC, and may be a potential new target for OSCC treatment.Keywords: peroxiredoxin 1, oral squamous cell carcinoma, lymph node metastasis, prognosis, nomogram