Malaria vaccines: identifying Plasmodium falciparum liver-stage targets
The development of a highly efficacious and durable vaccine for malaria remains a top priority for global health researchers. Despite the huge rise in recognition of malaria as a global health problem and the concurrent rise in funding over the past ten to fifteen years, malaria continues to remain...
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doaj-f2bdb5dc0ff94914ab585b9e3ed9bda62020-11-24T22:39:19ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-09-01610.3389/fmicb.2015.00965160257Malaria vaccines: identifying Plasmodium falciparum liver-stage targetsRhea Jessica Longley0Adrian VS Hill1Alexandra J Spencer2University of OxfordUniversity of OxfordUniversity of OxfordThe development of a highly efficacious and durable vaccine for malaria remains a top priority for global health researchers. Despite the huge rise in recognition of malaria as a global health problem and the concurrent rise in funding over the past ten to fifteen years, malaria continues to remain a widespread burden. The evidence of increasing resistance to anti-malarial drugs and insecticides is a growing concern. Hence, an efficacious and durable preventative vaccine for malaria is urgently needed. Vaccines are one of the most cost-effective tools and have successfully been used in the prevention and control of many diseases, however the development of a vaccine for the Plasmodium parasite has proved difficult. Given the early success of whole sporozoite mosquito-bite delivered vaccination strategies, we know that a vaccine for malaria is an achievable goal, with sub-unit vaccines holding great promise as they are simple and cheap to both manufacture and deploy. However a major difficulty in development of sub-unit vaccines lies within choosing the appropriate antigenic target from the 5000 or so genes expressed by the parasite. Given the liver-stage of malaria represents a bottle-neck in the parasite’s life cycle, there is widespread agreement that a multi-component sub-unit malaria vaccine should preferably contain a liver-stage target. In this article we review progress in identifying and screening P. falciparum liver-stage targets for use in a malaria vaccine.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00965/fullImmunityMalariaT cellsVaccineLiver-stage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rhea Jessica Longley Adrian VS Hill Alexandra J Spencer |
spellingShingle |
Rhea Jessica Longley Adrian VS Hill Alexandra J Spencer Malaria vaccines: identifying Plasmodium falciparum liver-stage targets Frontiers in Microbiology Immunity Malaria T cells Vaccine Liver-stage |
author_facet |
Rhea Jessica Longley Adrian VS Hill Alexandra J Spencer |
author_sort |
Rhea Jessica Longley |
title |
Malaria vaccines: identifying Plasmodium falciparum liver-stage targets |
title_short |
Malaria vaccines: identifying Plasmodium falciparum liver-stage targets |
title_full |
Malaria vaccines: identifying Plasmodium falciparum liver-stage targets |
title_fullStr |
Malaria vaccines: identifying Plasmodium falciparum liver-stage targets |
title_full_unstemmed |
Malaria vaccines: identifying Plasmodium falciparum liver-stage targets |
title_sort |
malaria vaccines: identifying plasmodium falciparum liver-stage targets |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2015-09-01 |
description |
The development of a highly efficacious and durable vaccine for malaria remains a top priority for global health researchers. Despite the huge rise in recognition of malaria as a global health problem and the concurrent rise in funding over the past ten to fifteen years, malaria continues to remain a widespread burden. The evidence of increasing resistance to anti-malarial drugs and insecticides is a growing concern. Hence, an efficacious and durable preventative vaccine for malaria is urgently needed. Vaccines are one of the most cost-effective tools and have successfully been used in the prevention and control of many diseases, however the development of a vaccine for the Plasmodium parasite has proved difficult. Given the early success of whole sporozoite mosquito-bite delivered vaccination strategies, we know that a vaccine for malaria is an achievable goal, with sub-unit vaccines holding great promise as they are simple and cheap to both manufacture and deploy. However a major difficulty in development of sub-unit vaccines lies within choosing the appropriate antigenic target from the 5000 or so genes expressed by the parasite. Given the liver-stage of malaria represents a bottle-neck in the parasite’s life cycle, there is widespread agreement that a multi-component sub-unit malaria vaccine should preferably contain a liver-stage target. In this article we review progress in identifying and screening P. falciparum liver-stage targets for use in a malaria vaccine. |
topic |
Immunity Malaria T cells Vaccine Liver-stage |
url |
http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00965/full |
work_keys_str_mv |
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1725709580914130944 |