Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer
Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render prostate tumor cells sensitive to antiandrogen therapy...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20820-x |
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doaj-f2c4c2cbe140413794b564af2e6c87752021-02-07T12:13:40ZengNature Publishing GroupNature Communications2041-17232021-02-0112111810.1038/s41467-020-20820-xDual functions of SPOP and ERG dictate androgen therapy responses in prostate cancerTiziano Bernasocchi0Geniver El Tekle1Marco Bolis2Azzurra Mutti3Arianna Vallerga4Laura P. Brandt5Filippo Spriano6Tanya Svinkina7Marita Zoma8Valentina Ceserani9Anna Rinaldi10Hana Janouskova11Daniela Bossi12Manuela Cavalli13Simone Mosole14Roger Geiger15Ze Dong16Cai-Guang Yang17Domenico Albino18Andrea Rinaldi19Peter Schraml20Simon Linder21Giuseppina M. Carbone22Andrea Alimonti23Francesco Bertoni24Holger Moch25Steven A. Carr26Wilbert Zwart27Marianna Kruithof-de Julio28Mark A. Rubin29Namrata D. Udeshi30Jean-Philippe P. Theurillat31Institute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaDepartment of Biomedical Research, University of BernInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaThe Broad Institute of MIT & HarvardInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute for Research in BiomedicineState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of SciencesInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaDepartment of Pathology and Molecular Pathology, University Hospital ZurichThe Netherlands Cancer Institute, Oncode InstituteInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaDepartment of Pathology and Molecular Pathology, University Hospital ZurichThe Broad Institute of MIT & HarvardThe Netherlands Cancer Institute, Oncode InstituteDepartment of Biomedical Research, Urology Research Laboratory, University of BernDepartment of Biomedical Research, University of BernThe Broad Institute of MIT & HarvardInstitute of Oncology Research, Faculty of Biomedical Sciences, Università della Svizzera italianaGene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render prostate tumor cells sensitive to antiandrogen therapy and that the presence of ERG promotes sensitivity to high dose of androgen and SPOP inhibition.https://doi.org/10.1038/s41467-020-20820-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Tiziano Bernasocchi Geniver El Tekle Marco Bolis Azzurra Mutti Arianna Vallerga Laura P. Brandt Filippo Spriano Tanya Svinkina Marita Zoma Valentina Ceserani Anna Rinaldi Hana Janouskova Daniela Bossi Manuela Cavalli Simone Mosole Roger Geiger Ze Dong Cai-Guang Yang Domenico Albino Andrea Rinaldi Peter Schraml Simon Linder Giuseppina M. Carbone Andrea Alimonti Francesco Bertoni Holger Moch Steven A. Carr Wilbert Zwart Marianna Kruithof-de Julio Mark A. Rubin Namrata D. Udeshi Jean-Philippe P. Theurillat |
| spellingShingle |
Tiziano Bernasocchi Geniver El Tekle Marco Bolis Azzurra Mutti Arianna Vallerga Laura P. Brandt Filippo Spriano Tanya Svinkina Marita Zoma Valentina Ceserani Anna Rinaldi Hana Janouskova Daniela Bossi Manuela Cavalli Simone Mosole Roger Geiger Ze Dong Cai-Guang Yang Domenico Albino Andrea Rinaldi Peter Schraml Simon Linder Giuseppina M. Carbone Andrea Alimonti Francesco Bertoni Holger Moch Steven A. Carr Wilbert Zwart Marianna Kruithof-de Julio Mark A. Rubin Namrata D. Udeshi Jean-Philippe P. Theurillat Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer Nature Communications |
| author_facet |
Tiziano Bernasocchi Geniver El Tekle Marco Bolis Azzurra Mutti Arianna Vallerga Laura P. Brandt Filippo Spriano Tanya Svinkina Marita Zoma Valentina Ceserani Anna Rinaldi Hana Janouskova Daniela Bossi Manuela Cavalli Simone Mosole Roger Geiger Ze Dong Cai-Guang Yang Domenico Albino Andrea Rinaldi Peter Schraml Simon Linder Giuseppina M. Carbone Andrea Alimonti Francesco Bertoni Holger Moch Steven A. Carr Wilbert Zwart Marianna Kruithof-de Julio Mark A. Rubin Namrata D. Udeshi Jean-Philippe P. Theurillat |
| author_sort |
Tiziano Bernasocchi |
| title |
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer |
| title_short |
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer |
| title_full |
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer |
| title_fullStr |
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer |
| title_full_unstemmed |
Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer |
| title_sort |
dual functions of spop and erg dictate androgen therapy responses in prostate cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-02-01 |
| description |
Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render prostate tumor cells sensitive to antiandrogen therapy and that the presence of ERG promotes sensitivity to high dose of androgen and SPOP inhibition. |
| url |
https://doi.org/10.1038/s41467-020-20820-x |
| work_keys_str_mv |
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