Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis
Background and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the asso...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi - SAGE Publishing
2011-12-01
|
Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320311422578 |
id |
doaj-f2cc5e59422e4348a472842d2dd053a1 |
---|---|
record_format |
Article |
spelling |
doaj-f2cc5e59422e4348a472842d2dd053a12021-05-02T12:13:23ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762011-12-011210.1177/1470320311422578Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysisTian-Biao Zhou0Chao Ou1Yuan-Han Qin2Li-Na Su3Feng-Ying Lei4Wei-Fang Huang5Yan-Jun Zhao6Yu-Sheng Pang7Kun-Peng Yang8Department of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Experimental Pathology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, ChinaDepartment of Internal Medicine, Township Health Centers of ShilLing in LongQuan district, ChengDu, ChinaBackground and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the association between ACE I/D gene polymorphism and idiopathic nephrotic syndrome (INS) susceptibility in children is still controversial. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and the onset of INS. Method : A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases, and eligible investigations were synthesized using the meta-analysis method. Results : Nine investigations were identified for the analysis of association between ACE I/D gene polymorphism and INS risk in children, including six in Asians, one study for Caucasians and two for Africans. There was positive association between D allele or DD genotype and INS susceptibility in Asians (OR = 1.75, p = 0.01; OR = 2.01, p = 0.02), but not for Caucasian children and Africans (for Caucasians, D: OR=1.35, p = 0.27, DD: OR = 0.95, p = 0.91; for Africans, D: OR = 1.70, p = 0.56, DD: OR = 1.60, p = 0.73). Furthermore, II homozygous seemed to play a positive role against INS onset for Asians (OR = 0.59, p = 0.02), but the link between II genotype and INS risk was not observed in Caucasian children and Africans (Caucasians: OR = 0.31, p = 0.06; Africans: OR = 0.50, p = 0.59). Conclusions : D allele and DD homozygous might become significant genetic molecular markers for INS susceptibility in Asian children, but the association was not observed in Caucasians or Africans. However, the conclusion from our study cannot be sustained and more investigations on larger sample in different populations are required to further clarify the role of D allele or DD homozygous in the onset of INS in difference races.https://doi.org/10.1177/1470320311422578 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tian-Biao Zhou Chao Ou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao Yu-Sheng Pang Kun-Peng Yang |
spellingShingle |
Tian-Biao Zhou Chao Ou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao Yu-Sheng Pang Kun-Peng Yang Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Tian-Biao Zhou Chao Ou Yuan-Han Qin Li-Na Su Feng-Ying Lei Wei-Fang Huang Yan-Jun Zhao Yu-Sheng Pang Kun-Peng Yang |
author_sort |
Tian-Biao Zhou |
title |
Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis |
title_short |
Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis |
title_full |
Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis |
title_fullStr |
Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis |
title_full_unstemmed |
Association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis |
title_sort |
association of angiotensin converting enzyme insertion/deletion gene polymorphism with idiopathic nephrotic syndrome susceptibility in children: a meta-analysis |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 1752-8976 |
publishDate |
2011-12-01 |
description |
Background and objective: Angiotensin converting enzyme (ACE) gene contains either an insertion (I) allele or a deletion (D) allele forming three potential genotypes: II, ID and DD. The D allele or DD genotype has been reported to be associated with higher plasma ACE level. An assessment of the association between ACE I/D gene polymorphism and idiopathic nephrotic syndrome (INS) susceptibility in children is still controversial. This meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and the onset of INS. Method : A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases, and eligible investigations were synthesized using the meta-analysis method. Results : Nine investigations were identified for the analysis of association between ACE I/D gene polymorphism and INS risk in children, including six in Asians, one study for Caucasians and two for Africans. There was positive association between D allele or DD genotype and INS susceptibility in Asians (OR = 1.75, p = 0.01; OR = 2.01, p = 0.02), but not for Caucasian children and Africans (for Caucasians, D: OR=1.35, p = 0.27, DD: OR = 0.95, p = 0.91; for Africans, D: OR = 1.70, p = 0.56, DD: OR = 1.60, p = 0.73). Furthermore, II homozygous seemed to play a positive role against INS onset for Asians (OR = 0.59, p = 0.02), but the link between II genotype and INS risk was not observed in Caucasian children and Africans (Caucasians: OR = 0.31, p = 0.06; Africans: OR = 0.50, p = 0.59). Conclusions : D allele and DD homozygous might become significant genetic molecular markers for INS susceptibility in Asian children, but the association was not observed in Caucasians or Africans. However, the conclusion from our study cannot be sustained and more investigations on larger sample in different populations are required to further clarify the role of D allele or DD homozygous in the onset of INS in difference races. |
url |
https://doi.org/10.1177/1470320311422578 |
work_keys_str_mv |
AT tianbiaozhou associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT chaoou associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT yuanhanqin associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT linasu associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT fengyinglei associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT weifanghuang associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT yanjunzhao associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT yushengpang associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis AT kunpengyang associationofangiotensinconvertingenzymeinsertiondeletiongenepolymorphismwithidiopathicnephroticsyndromesusceptibilityinchildrenametaanalysis |
_version_ |
1721491571847725056 |