Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy
Abstract Introduction Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure. Reports and discussion The frequency of DIC is higher than that of thrombotic thrombocyto...
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doaj-f2d96ee692064ff891ada60d245059fa2020-11-25T02:22:46ZengBMCThrombosis Journal1477-95602018-07-011611710.1186/s12959-018-0168-2Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathyHideo Wada0Takeshi Matsumoto1Kei Suzuki2Hiroshi Imai3Naoyuki Katayama4Toshiaki Iba5Masanori Matsumoto6Department of Molecular and Laboratory Medicine, Mie University Graduate School of MedicineDivision of Blood Transfusion Medicine and Cell Therapy, Mie University Graduate School of MedicineEmergency Critical Care Center, Mie University Graduate School of MedicineEmergency Critical Care Center, Mie University Graduate School of MedicineDepartment of Hematology and Oncology, Mie University Graduate School of MedicineDepartment of Emergency and Disaster Medicine, Juntendo University Graduate School of MedicineDepartment of Blood Transfusion Medicine, Nara Medical UniversityAbstract Introduction Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure. Reports and discussion The frequency of DIC is higher than that of thrombotic thrombocytopenic purpura (TTP). Many patients with TMA are diagnosed with DIC, but only about 15% of DIC patients are diagnosed with TMA. Hyperfibrinolysis is observed in most patients with DIC, and microangiopathic hemolytic anemia is observed in most patients with TMA. Markedly decreased ADAMTS13 activity, the presence of Shiga-toxin-producing Escherichia coli (STEC) and abnormality of the complement system are useful for the diagnosis of TTP, STEC-hemolytic uremic syndrome (HUS)and atypical HUS, respectively. However, there are no specific biomarkers for the diagnosis of DIC. Conclusion Although DIC and TMA are similar appearances, all coagulation, fibrinolysis and platelet systems are activated in DIC, and only platelets are markedly activated in TMA.http://link.springer.com/article/10.1186/s12959-018-0168-2DICTMAMicrovascular thrombosisHyperfibrinolysisOrgan failureMicroangiopathic hemolytic anemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hideo Wada Takeshi Matsumoto Kei Suzuki Hiroshi Imai Naoyuki Katayama Toshiaki Iba Masanori Matsumoto |
spellingShingle |
Hideo Wada Takeshi Matsumoto Kei Suzuki Hiroshi Imai Naoyuki Katayama Toshiaki Iba Masanori Matsumoto Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy Thrombosis Journal DIC TMA Microvascular thrombosis Hyperfibrinolysis Organ failure Microangiopathic hemolytic anemia |
author_facet |
Hideo Wada Takeshi Matsumoto Kei Suzuki Hiroshi Imai Naoyuki Katayama Toshiaki Iba Masanori Matsumoto |
author_sort |
Hideo Wada |
title |
Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy |
title_short |
Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy |
title_full |
Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy |
title_fullStr |
Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy |
title_full_unstemmed |
Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy |
title_sort |
differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy |
publisher |
BMC |
series |
Thrombosis Journal |
issn |
1477-9560 |
publishDate |
2018-07-01 |
description |
Abstract Introduction Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure. Reports and discussion The frequency of DIC is higher than that of thrombotic thrombocytopenic purpura (TTP). Many patients with TMA are diagnosed with DIC, but only about 15% of DIC patients are diagnosed with TMA. Hyperfibrinolysis is observed in most patients with DIC, and microangiopathic hemolytic anemia is observed in most patients with TMA. Markedly decreased ADAMTS13 activity, the presence of Shiga-toxin-producing Escherichia coli (STEC) and abnormality of the complement system are useful for the diagnosis of TTP, STEC-hemolytic uremic syndrome (HUS)and atypical HUS, respectively. However, there are no specific biomarkers for the diagnosis of DIC. Conclusion Although DIC and TMA are similar appearances, all coagulation, fibrinolysis and platelet systems are activated in DIC, and only platelets are markedly activated in TMA. |
topic |
DIC TMA Microvascular thrombosis Hyperfibrinolysis Organ failure Microangiopathic hemolytic anemia |
url |
http://link.springer.com/article/10.1186/s12959-018-0168-2 |
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