Cardiac-specific expression of the tetracycline transactivator confers increased heart function and survival following ischemia reperfusion injury.
Mice expressing the tetracycline transactivator (tTA) transcription factor driven by the rat α-myosin heavy chain promoter (α-MHC-tTA) are widely used to dissect the molecular mechanisms involved in cardiac development and disease. However, these α-MHC-tTA mice exhibit a gain-of-function phenotype c...
Main Authors: | Laila Elsherif, Xuerong Wang, Milana Grachoff, Beata M Wolska, David L Geenen, John P O'Bryan |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3260203?pdf=render |
Similar Items
-
Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice.
by: Megumi Takiguchi, et al.
Published: (2013-01-01) -
A previously functional tetracycline-regulated transactivator fails to target gene expression to the bone
by: Schmidt Eva, et al.
Published: (2011-08-01) -
An improved reprogrammable mouse model harbouring the reverse tetracycline-controlled transcriptional transactivator 3
by: S. Alaei, et al.
Published: (2016-07-01) -
Protective role of fibrates in cardiac ischemia/reperfusion
by: G Singh, et al.
Published: (2012-01-01) -
The protective effect of metformin on cardiac ischemia reperfusion.
by: Ru-Jiun Guan, et al.
Published: (2008)