Fusobacterium and Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer worldwide and its pathogenesis has been extensively explored over the past decades. Recently, microorganisms in the gastrointestinal tract have emerged as potential etiological agents. In particular, a direct proportional association between Fu...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-10-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00371/full |
id |
doaj-f2f3b0d27aa149d0bf6ace0fdd95aaaf |
---|---|
record_format |
Article |
spelling |
doaj-f2f3b0d27aa149d0bf6ace0fdd95aaaf2020-11-24T23:39:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-10-01810.3389/fonc.2018.00371371317Fusobacterium and Colorectal CancerZiwei Zhou0Jiewen Chen1Herui Yao2Hai Hu3Department of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, ChinaColorectal cancer (CRC) is the third most common cancer worldwide and its pathogenesis has been extensively explored over the past decades. Recently, microorganisms in the gastrointestinal tract have emerged as potential etiological agents. In particular, a direct proportional association between Fusobacterium and CRC has been described. Since then, the functional impact of Fusobacterium in CRC development has been studied using various mouse models. Although some epidemiologic studies did not establish an obvious relationship between Fusobacterium and CRC, numerous pathogenic mechanisms leading to the disease have been described. For instance, Fusobacterium can activate the E-cadherin/β-catenin signaling pathway and is associated with particular epigenetic phenotype, such as microsatellite instability (MSI) and hypermethylation, via its strong adhesive and invasive abilities resulting in malignant transformation of epithelial cells. Also, Fusobacterium could alter the tumor microenvironment (TME) significantly by myeloid-derived suppressor cells (MDSCs), tumor associated macrophages (TAMs), and tumor associated neutrophils (TANs) recruitment and local immune suppression. Herein, we provide an in-depth review of the relationship between Fusobacterium and colorectal cancer. In light of the emergence of microbiome-based therapeutics, potential therapies and preventive strategies for colorectal cancer related to Fusobacterium are also discussed.https://www.frontiersin.org/article/10.3389/fonc.2018.00371/fullFusobacteriumcolorectal cancertumor microenvironmentepigenetic changestumor immunity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ziwei Zhou Jiewen Chen Herui Yao Hai Hu |
spellingShingle |
Ziwei Zhou Jiewen Chen Herui Yao Hai Hu Fusobacterium and Colorectal Cancer Frontiers in Oncology Fusobacterium colorectal cancer tumor microenvironment epigenetic changes tumor immunity |
author_facet |
Ziwei Zhou Jiewen Chen Herui Yao Hai Hu |
author_sort |
Ziwei Zhou |
title |
Fusobacterium and Colorectal Cancer |
title_short |
Fusobacterium and Colorectal Cancer |
title_full |
Fusobacterium and Colorectal Cancer |
title_fullStr |
Fusobacterium and Colorectal Cancer |
title_full_unstemmed |
Fusobacterium and Colorectal Cancer |
title_sort |
fusobacterium and colorectal cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2018-10-01 |
description |
Colorectal cancer (CRC) is the third most common cancer worldwide and its pathogenesis has been extensively explored over the past decades. Recently, microorganisms in the gastrointestinal tract have emerged as potential etiological agents. In particular, a direct proportional association between Fusobacterium and CRC has been described. Since then, the functional impact of Fusobacterium in CRC development has been studied using various mouse models. Although some epidemiologic studies did not establish an obvious relationship between Fusobacterium and CRC, numerous pathogenic mechanisms leading to the disease have been described. For instance, Fusobacterium can activate the E-cadherin/β-catenin signaling pathway and is associated with particular epigenetic phenotype, such as microsatellite instability (MSI) and hypermethylation, via its strong adhesive and invasive abilities resulting in malignant transformation of epithelial cells. Also, Fusobacterium could alter the tumor microenvironment (TME) significantly by myeloid-derived suppressor cells (MDSCs), tumor associated macrophages (TAMs), and tumor associated neutrophils (TANs) recruitment and local immune suppression. Herein, we provide an in-depth review of the relationship between Fusobacterium and colorectal cancer. In light of the emergence of microbiome-based therapeutics, potential therapies and preventive strategies for colorectal cancer related to Fusobacterium are also discussed. |
topic |
Fusobacterium colorectal cancer tumor microenvironment epigenetic changes tumor immunity |
url |
https://www.frontiersin.org/article/10.3389/fonc.2018.00371/full |
work_keys_str_mv |
AT ziweizhou fusobacteriumandcolorectalcancer AT jiewenchen fusobacteriumandcolorectalcancer AT heruiyao fusobacteriumandcolorectalcancer AT haihu fusobacteriumandcolorectalcancer |
_version_ |
1725514184675819520 |