Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring
Abstract The contribution of endogenous insulin secretion to glycemic variability (GV) may differ between patients with impaired insulin secretion and those with preserved secretion. Our objective was to determine the linearity of the relationship between fasting C-peptide (CPR) as a marker of endog...
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doaj-f2f421d69d7b457c9cd3ca916d94963b2021-05-02T11:36:39ZengNature Publishing GroupScientific Reports2045-23222021-04-0111111010.1038/s41598-021-88749-9Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoringAika Miya0Akinobu Nakamura1Takahisa Handa2Hiroshi Nomoto3Hiraku Kameda4Kyu Yong Cho5So Nagai6Yoichi M. Ito7Hideaki Miyoshi8Tatsuya Atsumi9Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDivision of Diabetes and Endocrinology, Department of Medicine, NTT Sapporo Medical CenterDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDivision of Diabetes and Endocrinology, Department of Medicine, NTT Sapporo Medical CenterBiostatistics Division, Clinical Research and Medical Innovation Center, Hokkaido University HospitalDivision of Diabetes and Obesity, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityAbstract The contribution of endogenous insulin secretion to glycemic variability (GV) may differ between patients with impaired insulin secretion and those with preserved secretion. Our objective was to determine the linearity of the relationship between fasting C-peptide (CPR) as a marker of endogenous insulin secretion and GV in type 2 diabetes (T2DM), regardless of the type of antidiabetic treatment. We conducted a prospective observational study using continuous glucose monitoring obtained from 284 Japanese outpatients with T2DM with various HbA1c values and antidiabetic treatment. We constructed a prediction curve of base-line CPR versus coefficient of variation (CV) and identified the clinical factors associated with CV using multiple regression analysis. Fasting CPR showed a significant negative log-linear relationship with CV (P < 0.0001), and the latter being strikingly high in the low-CPR group. The multiple regression analysis showed that low CPR was an independent predictor of high CV (P < 0.0001). The significant correlations were sustained in both patients with/without insulin treatment. The contribution of endogenous insulin secretion to GV depends on the extent of insulin secretion impairment. Fasting CPR may represent a useful indicator of GV instability in T2DM.https://doi.org/10.1038/s41598-021-88749-9 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aika Miya Akinobu Nakamura Takahisa Handa Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Yoichi M. Ito Hideaki Miyoshi Tatsuya Atsumi |
spellingShingle |
Aika Miya Akinobu Nakamura Takahisa Handa Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Yoichi M. Ito Hideaki Miyoshi Tatsuya Atsumi Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring Scientific Reports |
author_facet |
Aika Miya Akinobu Nakamura Takahisa Handa Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Yoichi M. Ito Hideaki Miyoshi Tatsuya Atsumi |
author_sort |
Aika Miya |
title |
Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring |
title_short |
Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring |
title_full |
Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring |
title_fullStr |
Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring |
title_full_unstemmed |
Log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring |
title_sort |
log-linear relationship between endogenous insulin secretion and glycemic variability in patients with type 2 diabetes on continuous glucose monitoring |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-04-01 |
description |
Abstract The contribution of endogenous insulin secretion to glycemic variability (GV) may differ between patients with impaired insulin secretion and those with preserved secretion. Our objective was to determine the linearity of the relationship between fasting C-peptide (CPR) as a marker of endogenous insulin secretion and GV in type 2 diabetes (T2DM), regardless of the type of antidiabetic treatment. We conducted a prospective observational study using continuous glucose monitoring obtained from 284 Japanese outpatients with T2DM with various HbA1c values and antidiabetic treatment. We constructed a prediction curve of base-line CPR versus coefficient of variation (CV) and identified the clinical factors associated with CV using multiple regression analysis. Fasting CPR showed a significant negative log-linear relationship with CV (P < 0.0001), and the latter being strikingly high in the low-CPR group. The multiple regression analysis showed that low CPR was an independent predictor of high CV (P < 0.0001). The significant correlations were sustained in both patients with/without insulin treatment. The contribution of endogenous insulin secretion to GV depends on the extent of insulin secretion impairment. Fasting CPR may represent a useful indicator of GV instability in T2DM. |
url |
https://doi.org/10.1038/s41598-021-88749-9 |
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