Relative Adrenal Insufficiency in Cirrhotic Patients

Relative Adrenal Insufficiency in Cirrhotic Patients

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Relative adrenal insufficiency (RAI) was demonstrated in patients with cirrhosis and liver failure. A relationship appears to exist between the severity of the liver disease and the presence of RAI. Neither the mechanism nor the exact prevalence of RAI is fully understood. There is though a hypothes...

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Main Authors: Sotirios N. Anastasiadis, Olga I. Giouleme, Georgios S. Germanidis, Themistoklis G. Vasiliadis
Format: Article
Language:English
Published: SAGE Publishing 2015-08-01
Series:Clinical Medicine Insights: Gastroenterology
Online Access:https://doi.org/10.4137/CGast.S18127
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spelling doaj-f2f5332fc6cd4cb8850d5de337627a732020-11-25T02:29:30ZengSAGE PublishingClinical Medicine Insights: Gastroenterology1179-55222015-08-01810.4137/CGast.S18127Relative Adrenal Insufficiency in Cirrhotic PatientsSotirios N. Anastasiadis0Olga I. Giouleme1Georgios S. Germanidis2Themistoklis G. Vasiliadis33rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Greece.2nd Prop. Clinic of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Greece.1st Department of Internal Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Greece.3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Greece.Relative adrenal insufficiency (RAI) was demonstrated in patients with cirrhosis and liver failure. A relationship appears to exist between the severity of the liver disease and the presence of RAI. Neither the mechanism nor the exact prevalence of RAI is fully understood. There is though a hypothesis that low high-density lipoprotein (HDL) levels in this group of patients may be responsible for the insufficiency of cortisol. Several questions also arise about the way and the kind of cortisol (total cortisol, free cortisol, or even salivary cortisol) that should be measured. The presence of RAI in patients with cirrhosis is unquestionable, but still several studies should come up in order to properly define it and fully understand it.https://doi.org/10.4137/CGast.S18127
collection DOAJ
language English
format Article
sources DOAJ
author Sotirios N. Anastasiadis
Olga I. Giouleme
Georgios S. Germanidis
Themistoklis G. Vasiliadis
spellingShingle Sotirios N. Anastasiadis
Olga I. Giouleme
Georgios S. Germanidis
Themistoklis G. Vasiliadis
Relative Adrenal Insufficiency in Cirrhotic Patients
Clinical Medicine Insights: Gastroenterology
author_facet Sotirios N. Anastasiadis
Olga I. Giouleme
Georgios S. Germanidis
Themistoklis G. Vasiliadis
author_sort Sotirios N. Anastasiadis
title Relative Adrenal Insufficiency in Cirrhotic Patients
title_short Relative Adrenal Insufficiency in Cirrhotic Patients
title_full Relative Adrenal Insufficiency in Cirrhotic Patients
title_fullStr Relative Adrenal Insufficiency in Cirrhotic Patients
title_full_unstemmed Relative Adrenal Insufficiency in Cirrhotic Patients
title_sort relative adrenal insufficiency in cirrhotic patients
publisher SAGE Publishing
series Clinical Medicine Insights: Gastroenterology
issn 1179-5522
publishDate 2015-08-01
description Relative adrenal insufficiency (RAI) was demonstrated in patients with cirrhosis and liver failure. A relationship appears to exist between the severity of the liver disease and the presence of RAI. Neither the mechanism nor the exact prevalence of RAI is fully understood. There is though a hypothesis that low high-density lipoprotein (HDL) levels in this group of patients may be responsible for the insufficiency of cortisol. Several questions also arise about the way and the kind of cortisol (total cortisol, free cortisol, or even salivary cortisol) that should be measured. The presence of RAI in patients with cirrhosis is unquestionable, but still several studies should come up in order to properly define it and fully understand it.
url https://doi.org/10.4137/CGast.S18127
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AT olgaigiouleme relativeadrenalinsufficiencyincirrhoticpatients
AT georgiossgermanidis relativeadrenalinsufficiencyincirrhoticpatients
AT themistoklisgvasiliadis relativeadrenalinsufficiencyincirrhoticpatients
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