Correlation of insulin resistance extent with systemic inflammatory response and target organ damage in children with sepsis
Objective: To explore the correlation of insulin resistance (IR) extent with systemic inflammatory response and target organ damage in children with sepsis. Methods: A total of 70 patients with sepsis who were treated in our hospital between June 2013 and July 2016 were collected as observation g...
Main Author: | |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2017-08-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201716/25.pdf |
Summary: | Objective: To explore the correlation of insulin resistance (IR) extent with systemic
inflammatory response and target organ damage in children with sepsis. Methods: A total
of 70 patients with sepsis who were treated in our hospital between June 2013 and July 2016
were collected as observation group, 50 healthy children who received vaccination in our
hospital during the same period were selected as normal control group, the insulin resistance
index (HOMA-IR) of two groups of children were determined, the median of HOMA-IR of
observation group was referred to further divide them into high HOMA-IR group and low
HOMA-IR group, 35 cases in each group. The systemic inflammatory response and target
organ damage extent were compared between sepsis children with different HOMA-IR
levels. Results: HOMA-IR level in observation group was significantly higher than that in
normal control group. Serum inflammatory factors PCT, IL-1β, IL-8 and IL-10 contents in
high HOMA-IR group were significantly higher than those in low HOMA-IR group; serum
myocardial injury indexes CK, CK-MB and LDH contents were significantly higher than
those in low HOMA-IR group; serum liver injury indexes ALT, AST and TBIL contents were
significantly higher than those in low HOMA-IR group while ALB content was lower than
that in low HOMA-IR group; serum renal injury indexes Cr, BUN and CysC contents were
significantly higher than those in low HOMA-IR group. Conclusion: HOMA-IR level in
children with sepsis is higher than that in normal people, and HOMA-IR level is positively
correlated with systemic inflammatory response and target organ injury. |
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ISSN: | 1007-1237 1007-1237 |