Correlation of insulin resistance extent with systemic inflammatory response and target organ damage in children with sepsis

• Main Author: Min Liu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-08-01
• Series: Journal of Hainan Medical University
• Subjects: Sepsis; Insulin resistance; Systemic inflammatory response; Myocardial injury; Hepatic and renal function
• Online Access: http://www.hnykdxxb.com/PDF/201716/25.pdf

Objective: To explore the correlation of insulin resistance (IR) extent with systemic inflammatory response and target organ damage in children with sepsis. Methods: A total of 70 patients with sepsis who were treated in our hospital between June 2013 and July 2016 were collected as observation group, 50 healthy children who received vaccination in our hospital during the same period were selected as normal control group, the insulin resistance index (HOMA-IR) of two groups of children were determined, the median of HOMA-IR of observation group was referred to further divide them into high HOMA-IR group and low HOMA-IR group, 35 cases in each group. The systemic inflammatory response and target organ damage extent were compared between sepsis children with different HOMA-IR levels. Results: HOMA-IR level in observation group was significantly higher than that in normal control group. Serum inflammatory factors PCT, IL-1β, IL-8 and IL-10 contents in high HOMA-IR group were significantly higher than those in low HOMA-IR group; serum myocardial injury indexes CK, CK-MB and LDH contents were significantly higher than those in low HOMA-IR group; serum liver injury indexes ALT, AST and TBIL contents were significantly higher than those in low HOMA-IR group while ALB content was lower than that in low HOMA-IR group; serum renal injury indexes Cr, BUN and CysC contents were significantly higher than those in low HOMA-IR group. Conclusion: HOMA-IR level in children with sepsis is higher than that in normal people, and HOMA-IR level is positively correlated with systemic inflammatory response and target organ injury.