Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Demethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.

Bibliographic Details
Main Authors:	Gao-Qian Wang, Guo-Dong Chen, Sheng-Ying Qin, Dan Hu, Takayoshi Awakawa, Shao-Yang Li, Jian-Ming Lv, Chuan-Xi Wang, Xin-Sheng Yao, Ikuro Abe, Hao Gao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04298-2

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spelling	doaj-f30a4248c8d1480983d411fc8c04ad532021-05-11T10:21:36ZengNature Publishing GroupNature Communications2041-17232018-05-019111310.1038/s41467-018-04298-2Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavageGao-Qian Wang0Guo-Dong Chen1Sheng-Ying Qin2Dan Hu3Takayoshi Awakawa4Shao-Yang Li5Jian-Ming Lv6Chuan-Xi Wang7Xin-Sheng Yao8Ikuro Abe9Hao Gao10Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityClinical Experimental Center, First Affiliated Hospital of Jinan UniversityInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityGraduate School of Pharmaceutical Sciences, The University of TokyoInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityGraduate School of Pharmaceutical Sciences, The University of TokyoInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan UniversityDemethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.https://doi.org/10.1038/s41467-018-04298-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Gao-Qian Wang Guo-Dong Chen Sheng-Ying Qin Dan Hu Takayoshi Awakawa Shao-Yang Li Jian-Ming Lv Chuan-Xi Wang Xin-Sheng Yao Ikuro Abe Hao Gao
spellingShingle	Gao-Qian Wang Guo-Dong Chen Sheng-Ying Qin Dan Hu Takayoshi Awakawa Shao-Yang Li Jian-Ming Lv Chuan-Xi Wang Xin-Sheng Yao Ikuro Abe Hao Gao Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage Nature Communications
author_facet	Gao-Qian Wang Guo-Dong Chen Sheng-Ying Qin Dan Hu Takayoshi Awakawa Shao-Yang Li Jian-Ming Lv Chuan-Xi Wang Xin-Sheng Yao Ikuro Abe Hao Gao
author_sort	Gao-Qian Wang
title	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_short	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_full	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_fullStr	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_full_unstemmed	Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
title_sort	biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-05-01
description	Demethoxyviridin is a fungal steroid that inhibits a phosphatidylinositol 3-kinase, an enzyme contributing to tumor progression. Here, the authors elucidate the biosynthetic route that leads to the formation of demethoxyviridin in fungi.
url	https://doi.org/10.1038/s41467-018-04298-2
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Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

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