Ad- and AAV8-mediated ABCA1 gene therapy in a murine model with retinal ischemia/reperfusion injuries

Ad- and AAV8-mediated ABCA1 gene therapy in a murine model with retinal ischemia/reperfusion injuries

The anti-inflammatory molecule annexin A1 (ANXA1) determines the ultimate fate of retinal ganglion cell (RGC) in glaucoma. Cytoplasmic and extracellular ANXA1 facilitate resolution of inflammation. However, the nuclear translocation of ANXA1 induces RGC apoptosis in a murine glaucoma model, and the...

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Bibliographic Details
Main Authors:	Jing Luo, Shengli Wang, Zhenlong Zhou, Yin Zhao
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Series:	Molecular Therapy: Methods & Clinical Development
Subjects:	retina retinal ganglion cells RGCs ischemia reperfusion annexin A1 ABCA1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050121000127

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